| + |
WNT11 | up-regulates 
binding
|
MUSK |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195966 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22309736 |
We provide evidence that wnt9a and wnt11 bind directly to the extracellular domain of musk, to induce musk dimerization and subsequent tyrosine phosphorylation of the kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199641 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Musk has an extracellular region with homology to the frizzled crd,binding of which by wnt11 stimulates a pcp-like pathway during neuromuscolar development. Here, we show that in vivo, wnt11r and wnt4a initiate musk translocation from muscle membranes to recycling endosomes we provide evidence that wnt9a and wnt11 bind directly to the extracellular domain of musk, to induce musk dimerization and subsequent tyrosine phosphorylation of the kinase |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
WNT11 | up-regulates activity
binding
|
FZD3 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131634 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141428 |
|
|
Homo sapiens |
Lung Cancer Cell, Melanoma Cell |
| pmid |
sentence |
| 16273260 |
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERG | up-regulates quantity by expression 
transcriptional regulation
|
WNT11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21242973 |
ERG transcriptional networks in leukemia converge on WNT signaling targets. Specifically, WNT11 emerged as a direct target of ERG. Small interfering RNA (siRNA)-mediated knockdown of ERG confirmed downregulation of WNT11 transcripts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT11 | up-regulates
|
CHRNA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195963 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22309736 |
We identified five wnts (wnt9a, wnt9b, wnt10b, wnt11, and wnt16) that are able to stimulate achr clustering, of which wnt9a and wnt11 are expressed abundantly in developing muscles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
MUSK | up-regulates
binding
|
WNT11 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199518 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like ror, musk has an extracellular region with homolgogy to the frizzled crd, binding of which by wnt11 stimulates a pcp-like pathway during neuromuscular development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT11 | up-regulates activity
binding
|
Frizzled |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253127 |
|
|
Homo sapiens |
Lung Cancer Cell, Melanoma Cell |
| pmid |
sentence |
| 16273260 |
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT11 | up-regulates activity
binding
|
FZD6 |
0.66 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141431 |
|
|
Homo sapiens |
Lung Cancer Cell, Melanoma Cell |
| pmid |
sentence |
| 16273260 |
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOSTDC1 | down-regulates activity 
|
WNT11 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242721 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT11 | up-regulates activity
binding
|
FZD7 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78406 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 10862746 |
Consistent with this, xfz7 biochemically and functionally interacts with xwnt11 |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
WNT11 | up-regulates activity
binding
|
LRP6 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131637 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
3.0
WNT11
- 
- 