WNT Signaling

Pathway ID: SIGNOR-WNTView in NDEx

Description: The Wnt signaling pathway is a conserved pathway in animals, that directs cell proliferation, cell polarity and cell fate determination during embryonic development and tissue homeostasis. The extracellular Wnt signal stimulates several intra-cellular signal transduction cascades. The three best-characterized WNT pathways are shown: the canonical or Wnt/Beta-catenin dependent pathway and the non-canonical or Beta-catenin-independent pathway, that can be divided into the Planar Cell Polarity pathway, which is prominently involved in the regulation of cell polarity, cell motility and morphogenetic movements; and the Wnt/Ca2+ pathway, which regulates the transcription of genes controlling cell fate and cell migration.

Curated by: Anna Mattioni

31 Seed Entities

Organism:
Name Primary ID
LEF1 Q9UJU2
GSK3B/Axin/APC SIGNOR-C110
JUN P05412
CSNK1A1 P48729
RHOA P61586
MYC P01106
WNT3A P56704
Frizzled SIGNOR-PF11
ROCK1 Q13464
PRKACA P17612
WNT11 O96014
CREB1 P16220
ADCY1 Q08828
DKK1 O94907
SFRP1 Q8N474
Cell_migration SIGNOR-PH38
Survival SIGNOR-PH13
DVL1 O14640
WNT1 P04628
RAC1 P63000
Wnt SIGNOR-PF40
WNT5A P41221
Proliferation SIGNOR-PH4
DAAM1 Q9Y4D1
CTNNB1 P35222
MAPK8 P45983
LRP5 O75197
3',5'-cyclic AMP CHEBI:17489
WNT7A O00755
GNAS P63092
LRP6 O75581