WNT Signaling and Myogenesis

Pathway ID: SIGNOR-WNT_MyogenesisView in NDEx

Description: Wnt ligands activate a pathway that is related to a wide range of critical cell functions (e.g. cell division, migration, and synaptogenesis) and also play a fundamental role in skeletal muscle physiology. Signaling downstream of Frizzled receptors may lead to transcriptional activation of Myf5 through a Beta-catenin dependent pathway and MyoD via a Beta-catenin independent pathway, thus initiating myogenesis.

30 Seed Entities

Organism:
Name Primary ID
LEF1 Q9UJU2
GSK3B/Axin/APC SIGNOR-C110
PITX2 Q99697
JUN P05412
RHOA P61586
WNT3A P56704
Frizzled SIGNOR-PF11
ROCK1 Q13464
PRKACA P17612
WNT11 O96014
MYOD1 P15172
CREB1 P16220
ADCY1 Q08828
Brown_adipogenesis SIGNOR-PH27
DVL1 O14640
PAX3 P23760
WNT1 P04628
RAC1 P63000
Wnt SIGNOR-PF40
WNT5A P41221
MYF5 P13349
DAAM1 Q9Y4D1
Skeletal_muscle_differentiation SIGNOR-PH1
CTNNB1 P35222
MAPK8 P45983
LRP5 O75197
3',5'-cyclic AMP CHEBI:17489
WNT7A O00755
GNAS P63092
LRP6 O75581