Summary

Name HPRT1
Full Name Hypoxanthine-guanine phosphoribosyltransferase
Synonyms HGPRT, HGPRTase | HPRT
Primary ID P00492
Links - -
Type protein
Relations 6
Pathways Noonan syndrome, Nucleotide Salvage
Function Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification 5-phospho-α-D-ribose 1-diphosphate 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification guanine 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification guanosine 5'-monophosphate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification hypoxanthine 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification IMP 0.8
Publications: 1 Organism: Homo Sapiens