| + |
IRF7 | up-regulates quantity by expression 
transcriptional regulation
|
IFNA1 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146119 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16612387 |
Ikkalfa can also phosphorylate and activate interferon regulatory factor-7 (irf7), which is required for interferon-alfa (ifnalfa) production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
TLR7 | up-regulates quantity
|
IFNA1 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259248 |
|
|
Homo sapiens |
Plasmacytoid Dendritic Cell |
| pmid |
sentence |
| 15661881 |
TLR7 in pDC is functionally associated with the production of IFN-α- and IFN-regulated cytokines, similar to the role of TLR9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNA1 | up-regulates quantity by stabilization
|
ISGF3 complex |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240610 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22171011 |
IFN-I (IFN-_ and IFN-_) induces the assembly of IFN-stimulated gene factor 3 (ISGF3), a multimeric transcriptional activation complex composed of STAT1, STAT2, and IFN regulatory factor 9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
IFNA1 | up-regulates 
binding
|
IFNAR2 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104641 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278538 |
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNA1 | up-regulates activity
binding
|
IFNAR |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260334 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278538 |
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
IFNA1 | up-regulates
binding
|
IFNAR1 |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36622 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8181059 |
The present study describes a novel type i ifn receptor having the ability to bind and respond to several subtypes of ifn-a as well as to ifn-8. This 102 kda-51 kda receptor is essential for the activity of many type i ifns, as demonstrated with anti-receptor antibodies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNA1 | up-regulates activity
binding
|
IFNAR2 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219298 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11278538 |
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
IFNA1
- 
- 