Relation Results

Summary

Name IFNAR2
Full Name Interferon alpha/beta receptor 2
Synonyms IFN-R-2, IFN-alpha binding protein, IFN-alpha/beta receptor 2, Interferon alpha binding protein, Type I interferon receptor 2 | IFNABR, IFNARB
Primary ID P48551
Links - -
Type protein
Relations 9
Function Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT ...
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Type: Score: Layout: SPV 
0.3480.6720.7560.80.7250.6140.906CREBBPIFNAR2IFNB1IFNW1G8RGG88B68IRF9IFNA1IFNAR

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CREBBPup-regulates activity img/direct-activation.png acetylation IFNAR2 0.348
Identifier Residue Sequence Organism Cell Line
SIGNOR-217783 Lys399 SGPCERRkSPLQDPF Homo sapiens HEK-293 Cell
pmid sentence
By binding to IFNalphaR2 within the region where two adjacent proline boxes bear phospho-Ser364 and phospho-Ser384, CBP acetylates IFNalphaR2 on Lys399, which in turn serves as the docking site for interferon regulatory factor 9 (IRF9)RF9 interacts with the acetyl-Lys399 motif by means of its IRF homology2 (IH2) domain, leading to formation of the ISGF3 complex that includes IRF9, STAT1, and STAT2.
Publications: 1 Organism: Homo Sapiens
+ IFNB1up-regulates img/direct-activation.png binding IFNAR2 0.672
Identifier Residue Sequence Organism Cell Line
SIGNOR-105934 Homo sapiens
pmid sentence
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2.
Publications: 1 Organism: Homo Sapiens
+ IFNW1up-regulates img/direct-activation.png binding IFNAR2 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-105982 Homo sapiens
pmid sentence
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2.
Publications: 1 Organism: Homo Sapiens
+ G8RGG88B68up-regulates activity img/direct-activation.png chemical activation IFNAR2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259391 in vitro
pmid sentence
To significantly improve the pharmacological properties of the drug, a pegylated form of IFNalpha(2a) was developed (PEGASYS). This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side-chain of IFNalpha(2a). Here, we report the detailed structural, kinetic, and thermodynamic analysis of the binding to the extracellular domain of the receptor IFNAR2 of (40)PEG-IFNalpha(2a) and its isolated positional isomers modified at K31, K134, K131, K121, K164, and K70, respectively, in comparison with unmodified IFNalpha(2a).
Publications: 1 Organism: In Vitro
+ IRF9up-regulates activity img/direct-activation.png binding IFNAR2 0.725
Identifier Residue Sequence Organism Cell Line
SIGNOR-217779 Homo sapiens HEK-293 Cell
pmid sentence
By binding to IFNalphaR2 within the region where two adjacent proline boxes bear phospho-Ser364 and phospho-Ser384, CBP acetylates IFNalphaR2 on Lys399, which in turn serves as the docking site for interferon regulatory factor 9 (IRF9)RF9 interacts with the acetyl-Lys399 motif by means of its IRF homology2 (IH2) domain, leading to formation of the ISGF3 complex that includes IRF9, STAT1, and STAT2.
Publications: 1 Organism: Homo Sapiens
+ IFNB1up-regulates activity img/direct-activation.png binding IFNAR2 0.672
Identifier Residue Sequence Organism Cell Line
SIGNOR-219304 Chlorocebus aethiops COS Cell
pmid sentence
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2.
Publications: 1 Organism: Chlorocebus Aethiops
+ IFNA1up-regulates img/direct-activation.png binding IFNAR2 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-104641 Homo sapiens
pmid sentence
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2.
Publications: 1 Organism: Homo Sapiens
+ IFNAR2form complex img/form-complex.png binding IFNAR 0.906
Identifier Residue Sequence Organism Cell Line
SIGNOR-260333 Homo sapiens
pmid sentence
The human type I interferons, IFN-alpha, IFN-beta, and IFN-omega, induce somewhat different cellular effects but act through a common receptor complex, IFNAR, composed of subunits IFNAR-1 and IFNAR-2. Human IFNAR-2 binds all type I IFNs but with lower affinity and different specificity than the IFNAR complex. Human IFNAR-1 has low intrinsic binding of human IFNs but strongly affects the affinity and differential ligand specificity of the IFNAR complex.
Publications: 1 Organism: Homo Sapiens
+ IFNA1up-regulates activity img/direct-activation.png binding IFNAR2 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-219298 Chlorocebus aethiops COS Cell
pmid sentence
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2.
Publications: 1 Organism: Chlorocebus Aethiops
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