Relation Results

Summary

Name IFNA1
Full Name Interferon alpha-1/13
Synonyms IFN-alpha-1/13, Interferon alpha-D, LeIF D, IFNA13, IFNA13, IFNA13, IFNA13, IFNA13, IFNA13, IFNA13
Primary ID P01562
Links - -
Type protein
Relations 7
Pathways SARS-CoV CYTOKINE STORM
Function Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes

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Type: Score: Layout: SPV 
0.5650.6330.4060.6140.6510.453IRF7IFNA1IFNARTLR7IFNAR2IFNAR1ISGF3 complex

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Relations
Regulator
Mechanism
target
score ℹ
+ IRF7up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IFNA1 0.565
Identifier Residue Sequence Organism Cell Line
SIGNOR-146119 Homo sapiens
pmid sentence
Ikkalfa can also phosphorylate and activate interferon regulatory factor-7 (irf7), which is required for interferon-alfa (ifnalfa) production.
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ IFNA1up-regulates activity img/direct-activation.png binding IFNAR 0.633
Identifier Residue Sequence Organism Cell Line
SIGNOR-260334 Homo sapiens
pmid sentence
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2.
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ TLR7up-regulates quantity img/indirect-activation.png IFNA1 0.406
Identifier Residue Sequence Organism Cell Line
SIGNOR-259248 Homo sapiens Plasmacytoid Dendritic Cell
pmid sentence
TLR7 in pDC is functionally associated with the production of IFN-α- and IFN-regulated cytokines, similar to the role of TLR9.
Publications: 1 Organism: Homo Sapiens
+ IFNA1up-regulates img/direct-activation.png binding IFNAR2 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-104641 Homo sapiens
pmid sentence
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2.
Publications: 1 Organism: Homo Sapiens
+ IFNA1up-regulates img/direct-activation.png binding IFNAR1 0.651
Identifier Residue Sequence Organism Cell Line
SIGNOR-36622 Homo sapiens
pmid sentence
The present study describes a novel type i ifn receptor having the ability to bind and respond to several subtypes of ifn-a as well as to ifn-8. This 102 kda-51 kda receptor is essential for the activity of many type i ifns, as demonstrated with anti-receptor antibodies.
Publications: 1 Organism: Homo Sapiens
+ IFNA1up-regulates quantity by stabilization img/indirect-activation.png ISGF3 complex 0.453
Identifier Residue Sequence Organism Cell Line
SIGNOR-240610 Homo sapiens
pmid sentence
IFN-I (IFN-_ and IFN-_) induces the assembly of IFN-stimulated gene factor 3 (ISGF3), a multimeric transcriptional activation complex composed of STAT1, STAT2, and IFN regulatory factor 9.
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ IFNA1up-regulates activity img/direct-activation.png binding IFNAR2 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-219298 Chlorocebus aethiops COS Cell
pmid sentence
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2.
Publications: 1 Organism: Chlorocebus Aethiops
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