| + |
MARCHF1 | down-regulates quantity by destabilization 
polyubiquitination
|
HLA-DRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271412 |
Lys244 |
FIIKGLRkSNAAERR |
Homo sapiens |
|
| pmid |
sentence |
| 19117940 |
Two E3 ligases, MARCH I and MARCH VIII, have been shown to polyubiquitinate lysine residue 225 in the cytoplasmic tail of I-Abeta and HLA-DRbeta. We show that lysine residue 219 in the cytoplasmic tail of DRalpha is also subject to polyubiquitination. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MARCHF8 | down-regulates quantity by destabilization
polyubiquitination
|
HLA-DRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271411 |
Lys244 |
FIIKGLRkSNAAERR |
Homo sapiens |
|
| pmid |
sentence |
| 19117940 |
Two E3 ligases, MARCH I and MARCH VIII, have been shown to polyubiquitinate lysine residue 225 in the cytoplasmic tail of I-Abeta and HLA-DRbeta. We show that lysine residue 219 in the cytoplasmic tail of DRalpha is also subject to polyubiquitination. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RFX5 | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DRA |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266228 |
|
|
Homo sapiens |
Fibrosarcoma Cell Line |
| pmid |
sentence |
| 10586057 |
In this report, we correlate the loss of IFN-γ induction of MHC class II genes with the identification of a molecular defect in an essential regulator, namely RFX5. | We have further confirmed this finding by showing that new RFX5 leucine mutants created in vitro are incapable of transactivating a class II promoter, suggesting the identification of residues essential for RFX activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DRA |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254008 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 10886240 |
These results indicate that impaired up-regulation of HLA-DR in response to IFN-gamma results from insufficient induction of CIITA, but not from the signal from IFN-gamma receptor to the nucleus. The abnormal regulation of HLA-DR expression caused by impaired induction of CIITA may affect CD4+ T cell development in thymoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HLA-DRA | up-regulates
|
Membrane_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266630 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 21178476 |
Fusion with a B cell requires a ternary complex of gHgLgp42. Fusion is triggered by an interaction between gp42 and HLA class II. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRA |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254009 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11889043 |
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253998 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| + |
NFX1 | down-regulates quantity by repression
transcriptional regulation
|
HLA-DRA |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7964459 |
A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EBV gH:gL:gp42 | up-regulates activity
binding
|
HLA-DRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266628 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11864610 |
The EBV gp42 glycoprotein binds MHC class II molecules, playing a critical role in infection of B lymphocytes. The gp42 binds HLA-DR1 using a surface site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
3.0
HLA-DRA
- 
- 