Summary

Name FGA
Full Name Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]
Synonyms FIBA_HUMAN
Primary ID P02671
Links - -
Type protein
Relations 14
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage FGA 0.2
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage FGA 0.2
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage FGA 0.2
Publications: 3 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage FGA 0.2
Publications: 3 Organism: In Vitro
+ up-regulates img/indirect-activation.png Platelet_aggregation 0.7
Publications: 1
+ up-regulates img/direct-activation.png binding ITGAX 0.354
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FGA 0.558
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Fibrinogen 0.754
Publications: 1 Organism: In Vitro