| + |
F2 | up-regulates activity 
cleavage
|
Fibrinogen |
0.845 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263525 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29880919 |
Thrombin is a key enzyme in the pathway and cleaves fibrinogen to fibrin, which spontaneously forms the insoluble polymer that is the basis for the haemostatic plug. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
| + |
Fibrinogen | form complex 
cleavage
|
Fibrin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18544683 |
A fibrin clot is the final product of the blood clotting cascade. Thrombin catalyzes release of fibrinopeptide A from fibrinogen to create fibrin monomers, which then aggregate to protofibrils. Proteolytic release of fibrinopeptide B by thrombin permits lateral protofibril aggregation, resulting in a three-dimensional fibrin gel.|Fibrin clots were formed as described for turbidity experiments, in which the fibrinogen, calcium, and polyP (when included) were preincubated for 15 minutes before adding thrombin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
| + |
FGB | form complex
binding
|
Fibrinogen |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263391 |
|
|
in vitro |
|
| pmid |
sentence |
| 25427968 |
Fibrinogen is a plasma glycoprotein mainly synthesised by hepatocytes and circulating as a 340-kDa hexamer consisting of two sets of three different polypeptide chains (Aalpha, Bbeta, and gamma, encoded by the FGA, FGB, and FGG gene, respectively). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FGG | form complex
binding
|
Fibrinogen |
0.743 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263393 |
|
|
in vitro |
|
| pmid |
sentence |
| 25427968 |
Fibrinogen is a plasma glycoprotein mainly synthesised by hepatocytes and circulating as a 340-kDa hexamer consisting of two sets of three different polypeptide chains (Aalpha, Bbeta, and gamma, encoded by the FGA, FGB, and FGG gene, respectively). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FGA | form complex
binding
|
Fibrinogen |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263392 |
|
|
in vitro |
|
| pmid |
sentence |
| 25427968 |
Fibrinogen is a plasma glycoprotein mainly synthesised by hepatocytes and circulating as a 340-kDa hexamer consisting of two sets of three different polypeptide chains (Aalpha, Bbeta, and gamma, encoded by the FGA, FGB, and FGG gene, respectively). |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
Fibrinogen
CPX-1922