Summary

Name BRLF1
Full Name Replication and transcription activator
Synonyms Rta, Immediate-early protein Rta |
Primary ID P03209
Links - -
Type protein
Relations 3
Pathways EBV infection
Function Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor.

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Relations

Regulator Mechanism target score ℹ
+ BRLF1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation IFNB1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ BRLF1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation IRF3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ BRLF1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation IRF7 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection