| + |
PIN1 | down-regulates quantity by repression 
transcriptional regulation
|
IFNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252289 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16699525 |
To investigate the temporal regulation of IRF3-dependent transcription by Pin1, we used a rapid-response luciferase reporter gene. Real-time reporter gene assays showed that suppression of endogenous Pin1 expression substantially prolonged both IRF3-dependent transcription and IFN-beta promoter activation after poly(I)dotpoly(C) stimulation (Fig. 4c,d). Consistent with the inhibitory effects of Pin1 on the IFN-beta promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNB1 | up-regulates activity 
binding
|
IFNAR |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260335 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278538 |
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
IFNB1 | up-regulates 
|
JAK1 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10918594 |
Early events in type i ifn signaling are tyrosine phosphorylation of the type i ifn receptor subunits (ifnar1 and ifnar2), and the activation of the receptor-associated tyk-2 and jak-1 janus kinases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
IFNB1 | up-regulates
|
TYK2 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10918594 |
Early events in type i ifn signaling are tyrosine phosphorylation of the type i ifn receptor subunits (ifnar1 and ifnar2), and the activation of the receptor-associated tyk-2 and jak-1 janus kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
BRLF1 | down-regulates quantity by repression
transcriptional regulation
|
IFNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266646 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 20381110 |
Epstein-Barr Virus BRLF1 Inhibits Transcription of IRF3 and IRF7 and Suppresses Induction of Interferon-β. These results suggest that EBV Rta is capable of regulating the activation of the IFN-β promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
NKRF | down-regulates quantity by repression
transcriptional regulation
|
IFNB1 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266227 |
|
|
Mus musculus |
Swiss-3T3 Cell |
| pmid |
sentence |
| 10562553 |
Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAVS | up-regulates quantity by expression
transcriptional regulation
|
IFNB1 |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260372 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22588174 |
ECSIT enhances IPS-1-mediated IFN-Beta promoter activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF3 | up-regulates quantity by expression
transcriptional regulation
|
IFNB1 |
0.657 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252257 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16699525 |
Similarly, exogenous expression of wild-type Pin1 suppressed TLR3-mediated, IRF3-dependent activation of the IFN-beta promoter and reduced IFN-beta secretion in culture supernatants |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
Papain-like proteinase | down-regulates quantity by repression 
|
IFNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260277 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17761676 |
SARS-CoV PLpro domain inhibits activation of IFN-β promoter following engagement of TLR3 or RIG-I pathways independent of its protease activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNB1 | down-regulates quantity by repression
transcriptional regulation
|
MGMT |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255438 |
|
|
Homo sapiens |
Glioma Cell Line |
| pmid |
sentence |
| 17564708 |
we observed that IFN-beta sensitized TMZ-resistant glioma cells with the unmethylated MGMT promoter and that the mechanism of action was possibly due to attenuation of MGMT expression via induction of TP53. In this context, IFN-beta inactivates MGMT via p53 gene induction and enhances the therapeutic efficacy to TMZ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNB1 | up-regulates activity
binding
|
IFNAR1 |
0.864 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219301 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11278538 |
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
IFNB1 | up-regulates
binding
|
IFNAR1 |
0.864 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278538 |
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNB1 | up-regulates
binding
|
IFNAR2 |
0.665 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278538 |
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNB1 | up-regulates activity
binding
|
IFNAR2 |
0.665 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219304 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11278538 |
Ifn-alpha, ifn-beta, and ifn-omega, induce somewhat different cellular effects but act through a common receptor complex, ifnar, composed of subunits ifnar-1 and ifnar-2. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
IFNB1
- 
- 