Summary

Name APP
Full Name Amyloid beta A4 protein
Synonyms ABPP, APPI, APP, Alzheimer disease amyloid protein, Amyloid precursor protein, Beta-amyloid precursor protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II | A4, AD1
Primary ID P05067
Links - -
Type protein
Relations 14
Pathways Alzheimer Disease
Inhibitors 471905-41-6; dapt; Semagacestat; Avagacestat
Function Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation APP
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APP 0.16
Publications: 1 Organism: In Vitro
Pathways:Alzheimer Disease
+ img/unknown.png phosphorylation APP 0.17
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation APP
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown GSK3A 0.06
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ down-regulates img/direct_inhibition.png chemical inhibition APP
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage APP
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ up-regulates activity img/direct-activation.png binding NAE1
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ up-regulates img/indirect-activation.png unknown Amyloid fibril formation
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ down-regulates img/direct_inhibition.png chemical inhibition APP
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition APP
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown APP 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition APP
Publications: 1 Organism: Homo Sapiens