Summary

Name ITGB1
Full Name Integrin beta-1
Synonyms Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta | FNRB, MDF2, MSK12
Primary ID P05556
Links - -
Type protein
Relations 45
Pathways Integrin Signaling
Function Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation ITGB1 0.268
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding A4/b1 integrin 0.802
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.2
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding a7/b1 integrin 0.762
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding A6/b1 integrin 0.813
Publications: 1
Pathways:Integrin Signaling
+ form complex img/form-complex.png binding A11/b1 integrin 0.692
Publications: 1
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding A8/b1 integrin 0.811
Publications: 1
+ form complex img/form-complex.png binding A1/b1 integrin 0.747
Publications: 1
Pathways:Integrin Signaling
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding Av/b1 integrin 0.828
Publications: 1
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ down-regulates activity img/direct_inhibition.png binding ITGB1 0.32
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ITGB1 0.787
Publications: 2 Organism: Mus Musculus
Pathways:Integrin Signaling
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding A5/b1 integrin 0.912
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.284
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.399
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/indirect-activation.png PTK2 0.696
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ form complex img/form-complex.png binding A9/b1 integrin 0.772
Publications: 1
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding A2/b1 integrin 0.748
Publications: 1
+ form complex img/form-complex.png binding A10/b1 integrin 0.675
Publications: 1
+ up-regulates activity img/direct-activation.png binding ITGB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding A3/b1 integrin 0.796
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.298
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB1 0.762
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.2
Publications: 1 Organism: Rattus Norvegicus