4.0
Summary
| Name |  FHView Modifications |
| Full Name | Fumarate hydratase, mitochondrial |
| Synonyms | Fumarase | |
| Primary ID | P07954 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Pathways | Citric acid cycle - Krebs cycle |
| Function | Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PAK4 | down-regulates quantity 
phosphorylation
|
FH | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AMPK | up-regulates activity 
phosphorylation
|
FH | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Citric acid cycle - Krebs cycle | |||
| + | PRKDC | up-regulates activity
phosphorylation
|
FH | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | p38 | up-regulates activity
phosphorylation
|
FH | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle - Krebs cycle | |||
| + | FH | up-regulates quantity
chemical modification
|
(S)-malate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle - Krebs cycle | |||
| + | FH | down-regulates quantity
chemical modification
|
fumarate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle - Krebs cycle | |||
| + | FH | up-regulates activity
binding
|
ATF2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |