Summary

Name ATF2
Full Name Cyclic AMP-dependent transcription factor ATF-2
Synonyms cAMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, HB16, Histone acetyltransferase ATF2, cAMP response element-binding protein CRE-BP1 | CREB2, CREBP1
Primary ID P15336
Links - -
Type protein
Relations 55
Pathways COVID-19 Causal Network, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling
Function Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.59
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.38
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATF2 0.785
Publications: 2 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.725
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.785
Publications: 6 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.721
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.771
Publications: 4 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SAPK/JNK Signaling
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.683
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ATF2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FGF21 0.357
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATF2 0.612
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/indirect-activation.png transcriptional regulation IL6 0.306
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation YTHDC2 0.279
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ATF2 0.2
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.746
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SIRT4 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.517
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATF2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation POLB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLAT 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ST3GAL5 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATF2 0.577
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, TGF-beta Signaling
+ down-regulates activity img/direct_inhibition.png binding ATF2 0.531
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.2
Publications: 1 Organism: Homo Sapiens