| + |
AKT |
phosphorylation
|
HMOX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161283 |
Ser188 |
LYRSRMNsLEMTPAV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15581622 |
We have identified a putative consensus sequence for phosphorylation by akt/pkb of ho-1 at ser188. although the changes in activity are small, this study provides the first evidence for a role of the survival kinase akt in the regulation of ho-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
AKT1 |
phosphorylation
|
HMOX1 |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252506 |
Ser188 |
LYRSRMNsLEMTPAV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15581622 |
We have identified a putative consensus sequence for phosphorylation by akt/pkb of ho-1 at ser188. although the changes in activity are small, this study provides the first evidence for a role of the survival kinase akt in the regulation of ho-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BACH1 | down-regulates quantity 
transcriptional regulation
|
HMOX1 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14747657 |
These results indicate that ho-1 regulation involves a competition between the activator Nrf2 and the Bach1 repressor for interactions with the small Maf proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMOX1 | down-regulates activity
|
HBA1 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490932 |
Heme oxygenase (HO), by catabolizing heme to bile pigments, down-regulates cellular hemoprotein, hemoglobin, and heme |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFE2L2 | up-regulates quantity 
transcriptional regulation
|
HMOX1 |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259334 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31257023 |
Nrf2 accumulation in lung cancers causes the stabilization of Bach1 by inducing Ho1, the enzyme catabolizing heme. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
HMOX1 | down-regulates quantity
chemical modification
|
heme |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251911 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490932 |
Heme oxygenase (HO), by catabolizing heme to bile pigments, down-regulates cellular hemoprotein, hemoglobin, and heme |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259333 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16115609 |
The microsomal heme oxygenase system consists of heme oxygenase (HO) and NADPH-cytochrome P450 reductase, and plays a key role in the physiological catabolism of heme which yields biliverdin, carbon monoxide, and iron as the final products. Heme degradation proceeds essentially as a series of autocatalytic oxidation reactions involving heme bound to HO |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HMOX1 | up-regulates quantity by expression
transcriptional regulation
|
BAD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256304 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26722274 |
The results of the present study indicated that knockdown of HMOX-1 significantly enhanced doxorubicin-induced apoptosis and downregulated the expression of Bcl-2 and Bcl-xL in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMOX1 | up-regulates quantity by expression
transcriptional regulation
|
BCL2 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256303 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26722274 |
The results of the present study indicated that knockdown of HMOX-1 significantly enhanced doxorubicin-induced apoptosis and downregulated the expression of Bcl-2 and Bcl-xL in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFE2L2 | up-regulates quantity by expression 
transcriptional regulation
|
HMOX1 |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256276 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24024136 |
In both models, the inducer-modified and Nrf2-bound Keap1 is inactivated and, consequently, newly synthesized Nrf2 proteins bypass Keap1 and translocate into the nucleus, bind to the ARE and drive the expression of Nrf2 target genes such as NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HMOX1), glutamate-cysteine ligase (GCL) and glutathione S transferases (GSTs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
HMOX1 | down-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256559 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 26722274 |
Heme oxygenase-1 (HO-1) protects endothelial cells (EC) from undergoing apoptosis. These results indicated that HMOX-1 may be involved in conferring the chemoresistance of breast cancer cells, by preventing apoptosis and autophagy. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256302 |
|
|
Homo sapiens |
Umbilical Vein Endothelial Cell |
| pmid |
sentence |
| 21037234 |
In conclusion, AMPK stimulates HO-1 gene expression in human ECs via the Nrf2/antioxidant responsive element signaling pathway. The induction of HO-1 mediates the antiapoptotic effect of AMPK, and this may provide an important adaptive response to preserve EC viability during periods of metabolic stress. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HMOX1 | form complex 
binding
|
STC2/HMOX1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260388 |
|
|
|
COS-7 Cell |
| pmid |
sentence |
| 22503972 |
Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein.|Taken together, our findings point to three novel functions of STC2, and suggest that STC2 interacts with HO1 to form a eukaryotic 'stressosome' involved in the degradation of heme. |
|
| Publications: |
1 |
| + |
PRDM2 | up-regulates quantity by expression
transcriptional regulation
|
HMOX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241047 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8654390 |
We show that a portion of MTB-Zf, including an N-terminal zinc-finger domain, binds in vitro to MTE and that the transient coexpression of MTB-Zf cDNA leads to transativation of the heme-oxygenase-1 gene promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMOX1 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256295 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 17148680 |
Here we investigated the effects of HO-1 overexpression in murine and human melanoma cells. The most important findings of our study are that 1) overexpression of HO-1 augments the proliferation [.] |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
3.0
HMOX1
- 
- 