Summary

Name CYP19A1
Full Name Aromatase
Synonyms CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase | ARO1, CYAR, CYP19
Primary ID P11511
Links - -
Type protein
Relations 22
Pathways Luminal Breast Cancer, Sex Hormone Biosynthesis
Inhibitors androsta-1,4,6-triene-3,17-dione; letrozole; aminoglutethimide; anastrozole; exemestane; formestane; testolactone
Function A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247). Catalyzes three successive oxidations of C19 androgens

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CYP19A1 0.362
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification 17beta-estradiol 0.8
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Luminal Breast Cancer, Sex Hormone Biosynthesis
+ up-regulates quantity img/direct-activation.png chemical modification estrone 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Sex Hormone Biosynthesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP19A1 0.424
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CYP19A1 0.541
Publications: 1
Pathways:Luminal Breast Cancer
+ down-regulates activity img/direct_inhibition.png chemical inhibition CYP19A1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CYP19A1 0.522
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CYP19A1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP19A1 0.435
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CYP19A1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition CYP19A1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CYP19A1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP19A1 0.361
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CYP19A1 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CYP19A1 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP19A1 0.501
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CYP19A1 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CYP19A1 0.501
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP19A1 0.353
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer
+ down-regulates quantity img/direct_inhibition.png chemical modification androst-4-ene-3,17-dione 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Sex Hormone Biosynthesis
+ down-regulates quantity img/direct_inhibition.png chemical modification testosterone 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Sex Hormone Biosynthesis