4.0
Summary
| Name |  NR5A1View Modifications |
| Full Name | Steroidogenic factor 1 |
| Synonyms | SF-1, STF-1, hSF-1, Adrenal 4-binding protein, Fushi tarazu factor homolog 1, Nuclear receptor subfamily 5 group A member 1, Steroid hormone receptor Ad4BP | AD4BP, FTZF1, SF1 |
| Primary ID | Q13285 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Function | Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK7 | up-regulates 
phosphorylation
|
NR5A1 | 0.363 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | up-regulates activity
phosphorylation
|
NR5A1 | 0.453 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | TFIIH | up-regulates
phosphorylation
|
NR5A1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLK4 | up-regulates activity
phosphorylation
|
NR5A1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR5A1 | up-regulates quantity by expression 
transcriptional regulation
|
HSD3B2 | 0.405 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTEN | down-regulates activity 
dephosphorylation
|
NR5A1 | 0.255 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR5A1 | up-regulates quantity by expression
transcriptional regulation
|
STAR | 0.467 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR5A1 | down-regulates quantity by repression 
transcriptional regulation
|
CYP11B2 | 0.473 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR5A1 | up-regulates quantity by expression
transcriptional regulation
|
STAR | 0.467 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR5A1 | up-regulates quantity by expression
transcriptional regulation
|
CYP19A1 | 0.473 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR5A1 | up-regulates quantity by expression
transcriptional regulation
|
CYP19A1 | 0.473 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AR | up-regulates
binding
|
NR5A1 | 0.399 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR0B1 | down-regulates activity
binding
|
NR5A1 | 0.684 |
| Publications: | 1 | Organism: | Homo Sapiens | |