Summary

Name HARS1
Full Name Histidine--tRNA ligase, cytoplasmic
Synonyms Histidyl-tRNA synthetase, HisRS | HRS
Primary ID P12081
Links - -
Type protein
Relations 7
Pathways Translation elongation and termination
Function Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification His-tRNA(His) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Translation elongation and termination
+ down-regulates quantity img/direct_inhibition.png chemical modification histidine 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification alpha-aminoacyl-tRNA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Translation elongation and termination
+ up-regulates quantity img/direct-activation.png chemical modification diphosphate(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification AMP 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification tRNA(His) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification ATP(4-) 0.8
Publications: 1 Organism: Homo Sapiens