| + |
LYL1 | up-regulates quantity by expression 
transcriptional regulation
|
ANGPT2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198276 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22792348 |
Here, we identified angiopoietin-2 (ang-2), which encodes a major regulator of angiogenesis, as a direct transcriptional target of tal1,lyl1and lmo2. Knockdown of any of the three transcription factors in human blood and lymphatic endothelial cells caused ang-2 mrna and protein down-regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NKX2-5 | up-regulates quantity by expression
transcriptional regulation
|
LYL1 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19608273 |
Sequence analysis of the LYL1 promoter region revealed potential binding sites for transcription factors HOXA10, LMO2 and NKX2-5. Overexpression analysis, reporter gene assays and chromatin immuno-precipitation confirmed their activating impact on LYL1 expression. In conclusion, we identified multiple mechanisms which activate LYL1 in leukemic cells, including structural genomic alterations, namely microdeletion or amplification, together with the involvement of prominent oncogenic transcription factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LYL1 | up-regulates quantity by expression
transcriptional regulation
|
ERG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21536859 |
We further demonstrate that ERG expression in primary human T-ALL cells is mediated by the binding of other T-cell oncogenes SCL/TAL1, LMO2, and LYL1 in concert with ERG, FLI1, and GATA3 to the ERG +85 enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LYL1 | up-regulates quantity by expression
transcriptional regulation
|
MEF2C |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21261500 |
TAL1 and LYL1 are two leukemic members of the bHLH family of transcription factors. TAL1 and LYL1 activate expression of MEF2C |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LYL1
- 
- 