| + |
PRKCQ | up-regulates activity 
phosphorylation
|
FOSL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260878 |
Thr217 |
LEPEALHtPTLMTTP |
Homo sapiens |
|
| pmid |
sentence |
| 27816489 |
PKCθ-induced phosphorylations, in part at T217 and T227 residues, strongly and specifically increased Fra-1 transcriptional activity through the stimulation of Fra-1 transactivation domain, without affecting JUN factors. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260879 |
Thr227 |
LEPEALHtPTLMTTP |
Homo sapiens |
|
| pmid |
sentence |
| 27816489 |
PKCθ-induced phosphorylations, in part at T217 and T227 residues, strongly and specifically increased Fra-1 transcriptional activity through the stimulation of Fra-1 transactivation domain, without affecting JUN factors. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
JUN | up-regulates quantity by expression
transcriptional regulation
|
FOSL1 |
0.819 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261604 |
|
|
Homo sapiens |
HBE Cell |
| pmid |
sentence |
| 13679379 |
Members of the AP1 family distinctly regulated the fra-1 promoter. In particular, coexpression of c-Jun, Jun-D, and Fra-2 up-regulated fra-1 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | down-regulates activity 
binding
|
FOSL1 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240975 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9160889 |
USF specifically interacts with Fra1. USF was repressing this modest Fra1 transactivation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
F2R | up-regulates quantity by expression 
transcriptional regulation
|
FOSL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254848 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21072196 |
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOSL2 | up-regulates quantity by expression
transcriptional regulation
|
FOSL1 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261602 |
|
|
Homo sapiens |
HBE Cell |
| pmid |
sentence |
| 13679379 |
Members of the AP1 family distinctly regulated the fra-1 promoter. In particular, coexpression of c-Jun, Jun-D, and Fra-2 up-regulated fra-1 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JUND | up-regulates quantity by expression
transcriptional regulation
|
FOSL1 |
0.81 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261603 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 13679379 |
Members of the AP1 family distinctly regulated the fra-1 promoter. In particular, coexpression of c-Jun, Jun-D, and Fra-2 up-regulated fra-1 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Integrator complex | down-regulates quantity by repression 
transcriptional regulation
|
FOSL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261477 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2RL1 | up-regulates quantity by expression
transcriptional regulation
|
FOSL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254839 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21072196 |
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FOSL1
- 
- 