| + |
Integrator complex | down-regulates quantity by repression 
transcriptional regulation
|
H4C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261481 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25675981 |
Integrator-dependent function at promoter proximal sites that is unrelated to NELF-regulated pausing. Given its termination function at both the U2 snRNA and Histone H4 genes, we favor a model in which Integrator also has a termination function at promoter proximal sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INTS4 | form complex 
binding
|
Integrator complex |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261467 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
INTS9 | form complex
binding
|
Integrator complex |
0.789 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261471 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
INTS3 | form complex
binding
|
Integrator complex |
0.888 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261485 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
Integrator complex | down-regulates quantity by repression
transcriptional regulation
|
GADD45B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INTS13 | form complex
binding
|
Integrator complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261469 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
Integrator complex | down-regulates quantity by repression
transcriptional regulation
|
JUNB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261479 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INTS11 | form complex
binding
|
Integrator complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261462 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
INTS7 | form complex
binding
|
Integrator complex |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261464 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
INTS5 | form complex
binding
|
Integrator complex |
0.899 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261465 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
Integrator complex | up-regulates 
|
NcRNA_processing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261475 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26220997 |
In vivo knockdown and rescue experiments confirmed that the 3′ end processing of HVS pre-miRNAs also depends on Integrator activity. Interaction between Integrator and HVS primary miRNA (pri-miRNA) substrates that contain only the miRNA 3′ box was confirmed by coimmunoprecipitation and an in situ proximity ligation assay (PLA) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INTS10 | form complex
binding
|
Integrator complex |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261473 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
Integrator complex | down-regulates quantity by repression
transcriptional regulation
|
FOSL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261477 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INTS2 | form complex
binding
|
Integrator complex |
0.743 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261466 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
INTS12 | form complex
binding
|
Integrator complex |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261470 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
Integrator complex | down-regulates quantity by repression
transcriptional regulation
|
SDC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261480 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INTS8 | form complex
binding
|
Integrator complex |
0.73 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261472 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
POLR2A | up-regulates activity 
relocalization
|
Integrator complex |
0.647 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261476 |
|
|
in vitro |
|
| pmid |
sentence |
| 20457598 |
The pol II CTD specifically mediates recruitment of Integrator to the promoter of snRNA genes to activate transcription and direct 3' end processing of the transcripts. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
INTS1 | form complex
binding
|
Integrator complex |
0.887 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261468 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
INTS14 | form complex
binding
|
Integrator complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261474 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
INTS6 | form complex
binding
|
Integrator complex |
0.838 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261463 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
3.0
Integrator complex
CPX-6441