Summary

Name H2AX
Full Name Histone H2AX
Synonyms H2a/x, Histone H2A.X | H2AX
Primary ID P16104
Links - -
Type protein
Relations 19
Pathways FLT3-ITD signaling
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png monoubiquitination H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png ubiquitination H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H2AX 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png dephosphorylation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NBN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MDC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png translation regulation H2AX 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination H2AX 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png acetylation H2AX 0.2
Publications: 1 Organism: Homo Sapiens