Summary

Name DDX5
Full Name Probable ATP-dependent RNA helicase DDX5
Synonyms DEAD box protein 5, RNA helicase p68 | G17P1, HELR, HLR1
Primary ID P17844
Links - -
Type protein
Relations 13
Function Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png sumoylation DDX5 0.521
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DDX5 0.341
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation DDX5 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DDX5 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png post transcriptional regulation mir-10b 0.4
Publications: 1
+ up-regulates img/direct-activation.png binding DDX5 0.467
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DDX5
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.69
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC1 0.403
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding RNA helicases DDX5/DDX17 0.433
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding AR 0.328
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RUNX2 0.47
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding Microprocessor complex 0.712
Publications: 1