Relation Results

Summary

Name LAG3
Full Name Lymphocyte activation gene 3 protein
Synonyms LAG-3, CD antigen CD223 | FDC
Primary ID P18627
Links - -
Type protein
Relations 2
Pathways Mitochondrial dynamics in T cell exhaustion
Function Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inh ...
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Type: Score: Layout: SPV 
0.20.7LAG3Class II MHC:AntigenT cell exhaustion

Relations

Regulator
Mechanism
target
score
+ down-regulates activity img/direct_inhibition.png binding Class II MHC:Antigen 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275412 Homo sapiens T-lymphocyte
pmid sentence
Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png T cell exhaustion 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-275414 Homo sapiens T-lymphocyte
pmid sentence
Lag-3, Tim-3, and TIGIT are highly expressed on dysfunctional or exhausted T cells in chronic diseases such as chronic viral infection and cancer.
Publications: 1 Organism: Homo Sapiens
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