| + |
PRKCE | up-regulates 
phosphorylation
|
FGFR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201675 |
Ser782 |
PLEQYSPsYPDTRSS |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 23564461 |
Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase c(epsilon) regulates ras/mitogen-activated protein kinase signaling and neuronal differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGFR2 | up-regulates activity
phosphorylation
|
GLO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276184 |
Tyr136 |
GIAVPDVySACKRFE |
in vitro |
|
| pmid |
sentence |
| 34838714 |
We show that Glo1 activity is promoted by phosphorylation on Tyrosine 136 via multiple kinases. Glo1 Y136 is phosphorylated by multiple different kinases including all members of the Src family. Depletion of multiple different kinases led to a partial reduction in Glo1(Y136) phosphorylation. These included members of the Src family (Src, Yes1, FGR, and the related Abl1), and of the FAK, EPHA, FGFR, and VEGFR families (Figure 2B), suggesting phosphorylation of Glo1 on Y136 by multiple different kinases. In vitro kinase assays revealed that all the members of the Src family, as well as Epha5 and VEGFR3, can efficiently phosphorylate recombinant Glo1 on Y136 (Figure 2C–D). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FGFR2 |
phosphorylation
|
PTEN |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191793 |
Tyr240 |
RREDKFMyFEFPQPL |
Homo sapiens |
|
| pmid |
sentence |
| 22891331 |
Fgfrs phosphorylate pten at tyrosine 240 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGFR2 | up-regulates activity
phosphorylation
|
FGFR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276026 |
Tyr769 |
TLTTNEEyLDLSQPL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15629145 |
Our data also show that tyrosine 769 is not involved in the regulation of the endocytic process of KGFR.Following ligand binding, KGFR is rapidly autophosphorylated on specific tyrosine residues |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF6 | up-regulates
binding
|
FGFR2 |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42380 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663044 |
The nine known fgf ligands and the four signaling fgf receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual fgf receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
binding
|
FGFR2 |
0.898 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236033 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 7687739 |
The FGF-R2(IIIb) isoform displays high affinity for stromal cell-derived FGF-7, whereas the FGF-R2(IIIc) isoform does not recognize FGF-7 but has high affinity for the FGF-2 member of the FGF ligand family |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86121 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11390973 |
we determined the crystal structures of these two FGFR2 mutants in complex with fibroblast growth factor 2 (FGF2).These structures demonstrate that both mutations introduce additional interactions between FGFR2 and FGF2, thereby augmenting FGFR2-FGF2 affinity. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| Tissue: |
Prostate Gland Cancer Cell |
| + |
ponatinib | down-regulates activity 
chemical inhibition
|
FGFR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259278 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23468082 |
Ponatinib is an oral multitargeted kinase inhibitor that potently inhibits all 4 members of the FGFR family. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
regorafenib | down-regulates activity
chemical inhibition
|
FGFR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259178 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26254357 |
A novel multi-kinase inhibitor, regorafenib (Figure 1), inhibits vascular endothelial growth factor receptor (VEGFR) 1, VEGFR2, and VEGFR3, that play key roles in angiogenesis, and fibroblast growth factor receptor (FGFR) 1, platelet-derived growth factor receptor-β (PDGFR-β), tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 (TIE2) and the mutant oncogenic kinase KIT, RET, B-RAF |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF10 | up-regulates
binding
|
FGFR2 |
0.893 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-57380 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9582367 |
Rfgf-10 bound the kgfr with high affinity comparable to that of kgf |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42362 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663044 |
Fgf3, fgf7, fgf10 and fgf22 are ligands that activate fgfr2b. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FGF5 | up-regulates
binding
|
FGFR2 |
0.702 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-38995 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8386828 |
Fgf-5 can bind and induce autophosphorylation of human fgf receptors (fgfr) 1 and 2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF17 | up-regulates
binding
|
FGFR2 |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42365 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663044 |
Fgfs bind and activate high-affinity receptor tyrosine kinases. The cloning of fgf receptors (fgfrs) has identified four distinct genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF4 | up-regulates
binding
|
FGFR2 |
0.759 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42377 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663044 |
The nine known fgf ligands and the four signaling fgf receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual fgf receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-Hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylic acid | down-regulates activity
chemical inhibition
|
FGFR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258080 |
|
|
in vitro |
|
| pmid |
sentence |
| 22037378 |
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259704 |
|
|
in vitro |
|
| pmid |
sentence |
| 22037378 |
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
nintedanib | down-regulates activity
chemical inhibition
|
FGFR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257806 |
|
|
in vitro |
|
| pmid |
sentence |
| 18559524 |
In this report, we describe the preclinical profile of BIBF 1120, a combined VEGFR, FGFR, and PDGFR inhibitor currently entering phase III clinical studies in non–small cell lung carcinoma and other cancers. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FGFR2 | up-regulates 
|
MEK1/2 |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244868 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12270934 |
Fibroblast growth factor-2 (FGF-2), in the presence of dexamethasone, isobutylmethylxanthine, and insulin, induces a prolonged activation of the MEK/ERK signaling pathway, which lasts for at least 12 h post-induction, and this activity is less sensitive to the MEK inhibitors |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ADAM9 | down-regulates quantity by destabilization
cleavage
|
FGFR2 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260300 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22632802 |
Truncated FGFR2 was observed in cells transfected with wild-type ADAM9, but not in those with inactive mutant ADAM9 (Figure 5E). In line with this, cells transfected with wild-type ADAM9 showed reduced pErK1/2 in response to FGF2 as compared to controls or cells expressing mutant ADAM9.|Here we show that MT1-MMP forms a complex with FGFR2 and ADAM9 in osteoblasts and proteolytically inactivates ADAM9, hence protecting FGFR2 from ADAM9-mediated ectodomain shedding on the cell surface. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NANOGP8 | down-regulates quantity by repression 
transcriptional regulation
|
FGFR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266090 |
|
|
Bluetongue virus (serotype 10 / American isolate) |
Keratinocyte |
| pmid |
sentence |
| 23839044 |
Constitutive NanogP8 overexpression in adult L1 mice reduced CD34+α6+ and Lrig-1+ bulge stem cells, impaired keratinocyte migration, and repressed the expression of many stem cell-associated genes, including Bmp5, Fgfr2, Jmjd1a, and Jun. |
|
| Publications: |
1 |
Organism: |
Bluetongue Virus (serotype 10 / American Isolate) |
| + |
FGFR2 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17543283 |
Furthermore, in cultures receiving FGF-2 before adipogenic induction, mRNA expression of peroxisome proliferator-activated receptor gamma (PPARgamma), a key transcription factor in adipogenesis, was upregulated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BGJ-398 | down-regulates
chemical inhibition
|
FGFR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190266 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGFR2 | up-regulates activity
phosphorylation
|
FRS2 |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236950 |
|
|
Rattus norvegicus |
L-6 Myoblast Cell |
| pmid |
sentence |
| 9182757 |
In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
FGF3 | up-regulates
binding
|
FGFR2 |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42374 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663044 |
Using fgf 1 as an internal standard we have determined the relative activity of all the other members of the fgf family. These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve fgf signaling pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN11 | down-regulates activity
dephosphorylation
|
FGFR2 |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277030 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23420874 |
In forming this heterotetrameric complex Grb2 inhibits both the dephosphorylation of FGFR2 by Shp2 and the phosphorylation of Shp2 by FGFR2 (XREF_FIG, respectively).|Knockdown of Grb2 elevates Shp2 phosphorylation (XREF_FIG), strongly suggesting that the inability of Shp2 to interact directly with the receptor in the presence of Grb2 prevents FGFR2 kinase activity toward Shp2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGFR2 | up-regulates
phosphorylation
|
GRB2 |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197980 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22726438 |
Inhibition of basal fgf receptor signaling by dimeric grb2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Brivanib alaninate | down-regulates
chemical inhibition
|
FGFR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF18 | up-regulates
binding
|
FGFR2 |
0.729 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42368 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663044 |
Fgfs bind and activate high-affinity receptor tyrosine kinases. The cloning of fgf receptors (fgfrs) has identified four distinct genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGFR2 | up-regulates
|
MAP2K1 |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235337 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12270934 |
Fibroblast growth factor-2 (FGF-2), in the presence of dexamethasone, isobutylmethylxanthine, and insulin, induces a prolonged activation of the MEK/ERK signaling pathway, which lasts for at least 12 h post-induction, and this activity is less sensitive to the MEK inhibitors |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FGF1 | up-regulates
binding
|
FGFR2 |
0.909 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73811 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10618369 |
We have crystallized a complex between human FGF1 and a two-domain extracellular fragment of human FGFR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FGFR2
- 
- 