| + |
FGF2 | up-regulates 
|
Angiogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252279 |
|
|
|
|
| pmid |
sentence |
| 17326328 |
More than a dozen different proteins have been identified as angiogenic activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, transforming growth factor (TGF)-α, TGF-β, tumor necrosis factor (TNF)-α, platelet-derived endothelial growth factor, granulocyte colony-stimulating factor, placental growth factor, interleukin-8, hepatocyte growth factor, and epidermal growth factor |
|
| Publications: |
1 |
| + |
FGF2 | up-regulates quantity by expression
transcriptional regulation
|
TGFB1 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134791 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15780951 |
Fgf-2 and fgf-9 increased expression of other osteogenic factors bmp-2 and tgf-beta1, and endogenous fgf/ fgfr signaling is a positive upstream regulator of the bmp-2 gene in calvarial osteoblasts |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates 
binding
|
FGFR2 |
0.898 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236033 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 7687739 |
The FGF-R2(IIIb) isoform displays high affinity for stromal cell-derived FGF-7, whereas the FGF-R2(IIIc) isoform does not recognize FGF-7 but has high affinity for the FGF-2 member of the FGF ligand family |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86121 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11390973 |
we determined the crystal structures of these two FGFR2 mutants in complex with fibroblast growth factor 2 (FGF2).These structures demonstrate that both mutations introduce additional interactions between FGFR2 and FGF2, thereby augmenting FGFR2-FGF2 affinity. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| Tissue: |
Prostate Gland Cancer Cell |
| + |
FGF2 | up-regulates quantity by expression
transcriptional regulation
|
BMP2 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134785 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15780951 |
Furthermore, FGF-2 and FGF-9 increased expression of other osteogenic factors BMP-2 and TGFbeta-1. Meanwhile, blocking endogenous FGF signaling, using a virally transduced dominant-negative FGF receptor (FgfR), resulted in drastically reduced expression of the BMP-2 gene, demonstrating for the first time that endogenous FGF/FgfR signaling is a positive upstream regulator of the BMP-2 gene in calvarial osteoblasts |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
|
MAPK8 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20974802 |
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. External stimuli, which control the activity of mapks, such as phorbol esters and fibroblast growth factor 2 (fgf2) control the choice of the lrp6-ppps/tp kinase and regulate the amplitude of lrp6 phosphorylation and wnt/beta-catenin-dependent transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
binding
|
FGFR3 |
0.819 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195588 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Fgf-2 and fgf-9 increased expression of other osteogenic factors bmp-2 and tgf-beta1, and endogenous fgf/fgfr signaling is a positive upstream regulator of the bmp-2 gene in calvarial osteoblasts. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134788 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15780951 |
Fgf-2 and fgf-9 increased expression of other osteogenic factors bmp-2 and tgf-beta1, and endogenous fgf/fgfr signaling is a positive upstream regulator of the bmp-2 gene in calvarial osteoblasts. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FGF2 | down-regulates quantity by repression 
transcriptional regulation
|
HBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251795 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8142649 |
Basic fibroblast growth factor (bFGF) and transforming growth factor-beta 1 (TGF-beta) have both been shown to act on hematopoietic progenitor cells. bFGF antagonized the TGF-beta-mediated induction of hemoglobin in a dose-dependent manner, with 0.1 ng/mL bFGF inhibiting hemoglobin induction by 40% and 10 ng/mL bFGF completely abrogating hemoglobin production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15564063 |
Increased expression of RUNX2 in OA cartilage may contribute to increased expression of MMP-13. FGF2, which is present in OA synovial fluid, activated RUNX2 via the MEK/ERK pathway and increased MMP-13 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
|
MAPK14 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113649 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11781339 |
In these collagen gel cultures, p38 activation was induced more potently by fgf-2 treatment compared with that in proliferating cultures |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168992 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20974802 |
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. External stimuli, which control the activity of mapks, such as phorbol esters and fibroblast growth factor 2 (fgf2) control the choice of the lrp6-ppps/tp kinase and regulate the amplitude of lrp6 phosphorylation and wnt/beta-catenin-dependent transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HOXB7 | up-regulates quantity by expression
transcriptional regulation
|
FGF2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261639 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 8756643 |
Band shift and cotransfection experiments showed that HOXB7 directly transactivates the hFGF gene through one out of five putative homeodomain binding sites present in its promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
|
ERK1/2 |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20974802 |
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. External stimuli, which control the activity of mapks, such as phorbol esters and fibroblast growth factor 2 (fgf2) control the choice of the lrp6-ppps/tp kinase and regulate the amplitude of lrp6 phosphorylation and wnt/beta-catenin-dependent transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | down-regulates quantity by repression
transcriptional regulation
|
ALPL |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252194 |
|
|
Homo sapiens |
MC3T3-E1(C4) Cell |
| pmid |
sentence |
| 19049325 |
FGF2 increases PC-1 and Ank expression while inhibiting Tnap expression in primary pre-osteoblast cells. Additionally, we show that the induction of PC-1 by FGF2 is cell type specific and mediated by the transcription factor, Runx2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
|
MAPK3 |
0.602 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168995 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20974802 |
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. External stimuli, which control the activity of mapks, such as phorbol esters and fibroblast growth factor 2 (fgf2) control the choice of the lrp6-ppps/tp kinase and regulate the amplitude of lrp6 phosphorylation and wnt/beta-catenin-dependent transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | down-regulates quantity by repression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251796 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8142649 |
Basic fibroblast growth factor (bFGF) and transforming growth factor-beta 1 (TGF-beta) have both been shown to act on hematopoietic progenitor cells. bFGF antagonized the TGF-beta-mediated induction of hemoglobin in a dose-dependent manner, with 0.1 ng/mL bFGF inhibiting hemoglobin induction by 40% and 10 ng/mL bFGF completely abrogating hemoglobin production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
|
RUNX2 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15765505 |
Runx2 is an important mediator of the expression of bmp-2 in response to fgf stimulation in cranial bone development. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53 | down-regulates quantity by repression
transcriptional regulation
|
FGF2 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255431 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10029407 |
p53 transcriptionally activates expression of the genes encoding epidermal growth factor receptor, matrix metalloproteinase (MMP)-2, cathepsin D, and thrombospondin-1 but represses expression of the genes encoding basic fibroblast growth factor and multidrug resistance-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates quantity by expression
transcriptional regulation
|
ENPP1 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252191 |
|
|
Homo sapiens |
MC3T3-E1(C4) Cell |
| pmid |
sentence |
| 19049325 |
FGF2 increases PC-1 and Ank expression while inhibiting Tnap expression in primary pre-osteoblast cells. Additionally, we show that the induction of PC-1 by FGF2 is cell type specific and mediated by the transcription factor, Runx2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates quantity by expression
transcriptional regulation
|
ANKH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252193 |
|
|
Homo sapiens |
MC3T3-E1(C4) Cell |
| pmid |
sentence |
| 19049325 |
FGF2 increases PC-1 and Ank expression while inhibiting Tnap expression in primary pre-osteoblast cells. Additionally, we show that the induction of PC-1 by FGF2 is cell type specific and mediated by the transcription factor, Runx2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
binding
|
FGFR4 |
0.818 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-18564 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1385111 |
Our results establish an fgf binding profile for fgfr-4 with afgf having the highest affinity, followed by k-fgf/hst-1 and bfgf. In addition, fgf-6 was found to bind to fgfr-4 in ligand competition experiments. Ligands binding to fgfr-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
|
MAPK1 |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168989 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20974802 |
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. External stimuli, which control the activity of mapks, such as phorbol esters and fibroblast growth factor 2 (fgf2) control the choice of the lrp6-ppps/tp kinase and regulate the amplitude of lrp6 phosphorylation and wnt/beta-catenin-dependent transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
|
Gbeta |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269908 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20974802 |
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. External stimuli, which control the activity of mapks, such as phorbol esters and fibroblast growth factor 2 (fgf2) control the choice of the lrp6-ppps/tp kinase and regulate the amplitude of lrp6 phosphorylation and wnt/beta-catenin-dependent transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FGF2
- 
- 