Relation Results

Summary

Name FGFR4
Full Name Fibroblast growth factor receptor 4
Synonyms FGFR-4 | JTK2, TKF
Primary ID P22455
Links - -
Type protein
Relations 17
Pathways Rhabdomyosarcoma
Inhibitors nintedanib; BGJ-398; ponatinib
Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, dif ...
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Type: Score: Layout: SPV 
0.20.20.3520.4080.6780.3710.20.7260.6640.80.80.20.80.8230.815FGFR4GLO1STAT1STAT3FRS2PAX3PAX3-FOXO1FGF6FGF4nintedanibBGJ-398PAX7-FOXO1ponatinibFGF1FGF2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ FGFR4up-regulates activity img/direct-activation.png phosphorylation GLO1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276182 Tyr136 GIAVPDVySACKRFE in vitro
pmid sentence
We show that Glo1 activity is promoted by phosphorylation on Tyrosine 136 via multiple kinases. Glo1 Y136 is phosphorylated by multiple different kinases including all members of the Src family. Depletion of multiple different kinases led to a partial reduction in Glo1(Y136) phosphorylation. These included members of the Src family (Src, Yes1, FGR, and the related Abl1), and of the FAK, EPHA, FGFR, and VEGFR families (Figure 2B), suggesting phosphorylation of Glo1 on Y136 by multiple different kinases. In vitro kinase assays revealed that all the members of the Src family, as well as Epha5 and VEGFR3, can efficiently phosphorylate recombinant Glo1 on Y136 (Figure 2C–D).
Publications: 1 Organism: In Vitro
+ FGFR4up-regulates img/direct-activation.png phosphorylation FGFR4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-179776 Tyr642 RGVHHIDyYKKTSNG Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Binding of fgf to fgf receptors leads to receptor dimerization and subsequent tyrosine autophosphorylation and phosphorylation of target substrates. Autophosphorylation on tyrosine is considered to have at least two functions. One such function is the stimulation of the intrinsic protein tyrosine kinase activity by an allosteric mechanismthis antibody specifically recognizes tyr642/643 in fgfr-4.
Identifier Residue Sequence Organism Cell Line
SIGNOR-179780 Tyr643 GVHHIDYyKKTSNGR Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Binding of fgf to fgf receptors leads to receptor dimerization and subsequent tyrosine autophosphorylation and phosphorylation of target substrates. Autophosphorylation on tyrosine is considered to have at least two functions. One such function is the stimulation of the intrinsic protein tyrosine kinase activity by an allosteric mechanismthis antibody specifically recognizes tyr642/643 in fgfr-4.
Publications: 2 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ FGFR4up-regulates activity img/direct-activation.png phosphorylation STAT1 0.352
Identifier Residue Sequence Organism Cell Line
SIGNOR-251141 Tyr701 DGPKGTGyIKTELIS Homo sapiens HEK-293 Cell
pmid sentence
Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (top). all three FGFR family members examined here are able to lead to Stat activation. Expression of the 'TDII-like' derivatives of FGFR1, FGFR3, and FGFR4, as well as myrR1-WT, led to phosphorylation of both Stat1 and Stat3.
Publications: 1 Organism: Homo Sapiens
+ FGFR4up-regulates activity img/direct-activation.png phosphorylation STAT3 0.408
Identifier Residue Sequence Organism Cell Line
SIGNOR-251142 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (top). all three FGFR family members examined here are able to lead to Stat activation. Expression of the 'TDII-like' derivatives of FGFR1, FGFR3, and FGFR4, as well as myrR1-WT, led to phosphorylation of both Stat1 and Stat3.
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ FGFR4up-regulates activity img/direct-activation.png phosphorylation FGFR4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251140 Tyr754 LLAVSEEyLDLRLTF in vitro
pmid sentence
Analysis of the major autophosphorylation site Y754F mutant of FGFR-4 showed that binding of p85 and its serine phosphorylation were independent of receptor autophosphorylation at this site.
Publications: 1 Organism: In Vitro
Pathways:Rhabdomyosarcoma
+ FGFR4up-regulates activity img/direct-activation.png phosphorylation FRS2 0.678
Identifier Residue Sequence Organism Cell Line
SIGNOR-242661 Rattus norvegicus
pmid sentence
In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway.
Publications: 1 Organism: Rattus Norvegicus
+ PAX3up-regulates quantity by expression img/direct-activation.png transcriptional regulation FGFR4 0.371
Identifier Residue Sequence Organism Cell Line
SIGNOR-251572 Homo sapiens
pmid sentence
FGFR4 is a transcriptional target of PAX3 and the PAX3-FOXO1 fusion protein found in ARMS.
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ PAX3-FOXO1up-regulates quantity by expression img/direct-activation.png transcriptional regulation FGFR4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251569 Homo sapiens
pmid sentence
Several deregulated signalling pathways enhance cell growth by modulating cell-cycle regulatory factors in RMS. The most frequently affected signalling pathways include the insulin-like growth factor (IGF), fibroblast growth factor (FGF), hepatocyte growth factor, and platelet-derived growth factor. In ARMS, PAX-FOXO1 activates these pathways by transcriptional activation of receptor genes including IGFR1, FGFR4, MET (c-Met), and PDGFRA.
Publications: 1 Organism: Homo Sapiens
+ FGF6up-regulates img/direct-activation.png binding FGFR4 0.726
Identifier Residue Sequence Organism Cell Line
SIGNOR-18570 Homo sapiens
pmid sentence
Our results establish an fgf binding profile for fgfr-4 with afgf having the highest affinity, followed by k-fgf/hst-1 and bfgf. In addition, fgf-6 was found to bind to fgfr-4 in ligand competition experiments. Ligands binding to fgfr-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides.
Publications: 1 Organism: Homo Sapiens
+ FGF4up-regulates img/direct-activation.png binding FGFR4 0.664
Identifier Residue Sequence Organism Cell Line
SIGNOR-18567 Homo sapiens
pmid sentence
Our results establish an fgf binding profile for fgfr-4 with afgf having the highest affinity, followed by k-fgf/hst-1 and bfgf. In addition, fgf-6 was found to bind to fgfr-4 in ligand competition experiments. Ligands binding to fgfr-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides.
Publications: 1 Organism: Homo Sapiens
+ nintedanibdown-regulates activity img/direct_inhibition.png chemical inhibition FGFR4 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257803 in vitro
pmid sentence
In this report, we describe the preclinical profile of BIBF 1120, a combined VEGFR, FGFR, and PDGFR inhibitor currently entering phase III clinical studies in non–small cell lung carcinoma and other cancers.
Publications: 1 Organism: In Vitro
+ BGJ-398down-regulates img/direct_inhibition.png chemical inhibition FGFR4 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-190272 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ PAX7-FOXO1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FGFR4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251565 Homo sapiens
pmid sentence
Several deregulated signalling pathways enhance cell growth by modulating cell-cycle regulatory factors in RMS. The most frequently affected signalling pathways include the insulin-like growth factor (IGF), fibroblast growth factor (FGF), hepatocyte growth factor, and platelet-derived growth factor. In ARMS, PAX-FOXO1 activates these pathways by transcriptional activation of receptor genes including IGFR1, FGFR4, MET (c-Met), and PDGFRA.
Publications: 1 Organism: Homo Sapiens
+ ponatinibdown-regulates activity img/direct_inhibition.png chemical inhibition FGFR4 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259280 Homo sapiens
pmid sentence
Ponatinib is an oral multitargeted kinase inhibitor that potently inhibits all 4 members of the FGFR family.
Publications: 1 Organism: Homo Sapiens
+ FGF1up-regulates img/direct-activation.png binding FGFR4 0.823
Identifier Residue Sequence Organism Cell Line
SIGNOR-18454 Homo sapiens
pmid sentence
Our results establish an fgf binding profile for fgfr-4 with afgf having the highest affinity, followed by k-fgf/hst-1 and bfgf. In addition, fgf-6 was found to bind to fgfr-4 in ligand competition experiments. Ligands binding to fgfr-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides.
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ FGF2up-regulates img/direct-activation.png binding FGFR4 0.815
Identifier Residue Sequence Organism Cell Line
SIGNOR-18564 Homo sapiens
pmid sentence
Our results establish an fgf binding profile for fgfr-4 with afgf having the highest affinity, followed by k-fgf/hst-1 and bfgf. In addition, fgf-6 was found to bind to fgfr-4 in ligand competition experiments. Ligands binding to fgfr-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides.
Publications: 1 Organism: Homo Sapiens
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