| + |
PRKCA | down-regulates 
phosphorylation
|
CFL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198478 |
Ser23 |
NDMKVRKsSTPEEVK |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 22855535 |
Pkc_ phosphorylates cofilin at ser-23 and/or ser-24 during degranulationthese results indicate that a novel pkc_-mediated phosphorylation event regulates cofilin by inhibiting its ability to depolymerize f-actin and bind to 14-3-3_, thereby promoting f-actin polymerization |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198482 |
Ser24 |
DMKVRKSsTPEEVKK |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 22855535 |
Pkc_ phosphorylates cofilin at ser-23 and/or ser-24 during degranulationthese results indicate that a novel pkc_-mediated phosphorylation event regulates cofilin by inhibiting its ability to depolymerize f-actin and bind to 14-3-3_, thereby promoting f-actin polymerization |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
TESK2 | down-regulates activity
phosphorylation
|
CFL1 |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108753 |
Ser3 |
sGVAVSDG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11418599 |
Like tesk1, tesk2 phosphorylated cofilin specifically at ser-3 and induced formation of actin stress fibers and focal adhesions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TESK1 | down-regulates activity
phosphorylation
|
CFL1 |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246723 |
Ser3 |
sGVAVSDG |
Homo sapiens |
Testis |
| pmid |
sentence |
| 11418599 |
Like TESK1, TESK2 phosphorylated cofilin specifically at Ser-3 and induced formation of actin stress fibers and focal adhesionsExpression of cofilin or S3A-cofilin into HeLa cells induced marked decreases in rhodamine-phalloidin staining due to the actin binding and -depolymerizing activity of cofilin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106777 |
Ser3 |
sGVAVSDG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11294912 |
These results suggest that TESK1 functions downstream of integrins and plays a key role in integrin-mediated actin reorganization, presumably through phosphorylating and inactivating cofilin. We propose that tesk1 and lim-kinases commonly phosphorylate cofilin but are regulated in different ways and play distinct roles in actin reorganization in living cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ILK | down-regulates
phosphorylation
|
CFL1 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160756 |
Ser3 |
sGVAVSDG |
Homo sapiens |
|
| pmid |
sentence |
| 18252715 |
Actin (de)polymerization is regulated by cofilin, the ser(3) phosphorylation (ps(3)cofilin) of which inhibits its actin-severing activity. To determine how ilk regulates ps(3)cofilin, we examined the effects of ilk on ps(3)cofilin using normal rie1 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LIMK2 | down-regulates activity
phosphorylation
|
CFL1 |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105098 |
Ser3 |
sGVAVSDG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11171090 |
We report here that limk1 and limk2 phosphorylate both cofilin and actin-depolymerizing factor (adf) specifically at ser-3 and exhibit partially distinct substrate specificity when tested using site-directed cofilin mutants as substrates |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SSH1 | up-regulates activity 
dephosphorylation
|
CFL1 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248762 |
Ser3 |
sGVAVSDG |
Homo sapiens |
|
| pmid |
sentence |
| 14531860 |
Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.|Cofilin, a key regulator of actin filament dynamics, is inactivated by phosphorylation at Ser-3 by LIM-kinases and is reactivated by dephosphorylation by a family of protein phosphatases, termed Slingshot (SSH). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SSH3 | up-regulates activity
dephosphorylation
|
CFL1 |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248759 |
Ser3 |
sGVAVSDG |
Homo sapiens |
|
| pmid |
sentence |
| 14531860 |
Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.|Cofilin, a key regulator of actin filament dynamics, is inactivated by phosphorylation at Ser-3 by LIM-kinases and is reactivated by dephosphorylation by a family of protein phosphatases, termed Slingshot (SSH). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LIMK1 | down-regulates
phosphorylation
|
CFL1 |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159885 |
Ser3 |
sGVAVSDG |
Homo sapiens |
|
| pmid |
sentence |
| 18079118 |
Our results suggest that limk1-mediated cofilin phosphorylation is required for accurate spindle orientation by stabilizing cortical actin networks during mitosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKD1 | down-regulates activity
phosphorylation
|
CFL1 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275944 |
Ser3 |
sGVAVSDG |
|
|
| pmid |
sentence |
| 19329994 |
PKD1 regulates cofilin S3-phosphorylation|Both, oxidative stress as well as RhoA activation enhanced cofilin phosphorylation at S3, implicating an increased inhibition due to PKD1-mediated signalling events |
|
| Publications: |
1 |
| + |
PDXP | down-regulates activity
dephosphorylation
|
CFL1 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248764 |
Ser3 |
sGVAVSDG |
in vitro |
|
| pmid |
sentence |
| 15580268 |
Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics|Cofilin is a key regulator of actin cytoskeletal dynamics whose activity is controlled by phosphorylation of a single serine residue. We report the biochemical isolation of chronophin (CIN), a unique cofilin-activating phosphatase of the haloacid dehalogenase (HAD) superfamily. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SSH2 | up-regulates activity
dephosphorylation
|
CFL1 |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248733 |
Ser3 |
sGVAVSDG |
Homo sapiens |
|
| pmid |
sentence |
| 14531860 |
Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.|Cofilin, a key regulator of actin filament dynamics, is inactivated by phosphorylation at Ser-3 by LIM-kinases and is reactivated by dephosphorylation by a family of protein phosphatases, termed Slingshot (SSH). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | down-regulates
phosphorylation
|
CFL1 |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188352 |
Tyr68 |
GQTVDDPyATFVKML |
Homo sapiens |
|
| pmid |
sentence |
| 19802004 |
Tyrosine phosphorylation of cofilin at y68 by v-src leads to its degradation through ubiquitin-proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
PTEN | up-regulates activity
dephosphorylation
|
CFL1 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276980 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22317922 |
Unexpectedly, cofilin-1 activation by PGE 2 was mediated by the protein phosphatase activity of PTEN (phosphatase and tensin homolog deleted on chromosome 10), with which it directly associated.|Unexpectedly, cofilin-1 dephosphorylation and activation in our model was mediated by the protein phosphatase activity of PTEN. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CFL1 | down-regulates 
|
Axonal_growth_cone_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16226035 |
This observation suggests that Slit2 may require the Robo2 and Robo3 receptors in this process . Slit2 causes the miRNA miR-182 to release cofilin1 mRNA, potentiating cofilin1 local translation and resulting in growth cone collapse. The use of morpholinos or RNAi to knockdown robo2 and robo3 in X. laevis RGCs, would be useful to further confirm that Robo2 and Robo3 are the receptors involved in Slit2-dependent cofilin1 translation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
ROBO2 | up-regulates quantity by expression
post transcriptional regulation
|
CFL1 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268378 |
|
|
in vitro |
|
| pmid |
sentence |
| 16226035 |
Slit2 causes the miRNA miR-182 to release cofilin1 mRNA, potentiating cofilin1 local translation and resulting in growth cone collapse. The use of morpholinos or RNAi to knockdown robo2 and robo3 in X. laevis RGCs, would be useful to further confirm that Robo2 and Robo3 are the receptors involved in Slit2-dependent cofilin1 translation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Axon guidance |
| + |
ROBO3 | up-regulates quantity by expression
post transcriptional regulation
|
CFL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268379 |
|
|
in vitro |
|
| pmid |
sentence |
| 16226035 |
Slit2 causes the miRNA miR-182 to release cofilin1 mRNA, potentiating cofilin1 local translation and resulting in growth cone collapse. The use of morpholinos or RNAi to knockdown robo2 and robo3 in X. laevis RGCs, would be useful to further confirm that Robo2 and Robo3 are the receptors involved in Slit2-dependent cofilin1 translation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Axon guidance |
| + |
CFL1 | down-regulates quantity
binding
|
F-actin_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261836 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 27871158 |
Cofilin also binds to actin and contributes to the disassembly of actin filaments and the subsequent release of actin monomers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
3.0
CFL1
- 
- 