| + |
AKT1 | up-regulates 
phosphorylation
|
EIF4B |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252520 |
Ser422 |
RERSRTGsESSQTGT |
Homo sapiens |
|
| pmid |
sentence |
| 18836482 |
Using an in vitro kinase assay, we found that pkb can directly phosphorylate eif4b on serine 422 (ser422). This was prevented by pretreatment of cells with the phosphatidylinositol 3-kinase (pi3k) inhibitor ly294002 or pharmacological inhibition of pkb. Phosphorylation regultes the activation of eukaryotic translation initiation factor 4b. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6K | up-regulates
phosphorylation
|
EIF4B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252783 |
Ser422 |
RERSRTGsESSQTGT |
Homo sapiens |
|
| pmid |
sentence |
| 15071500 |
S6k1/s6k2 specifically phosphorylate ser422 in vitro. Substitution of ser422 with ala results in a loss of activity in an in vivo translation assay, indicating that phosphorylation of this site plays an important role in eif4b function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KB1 | up-regulates
phosphorylation
|
EIF4B |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123997 |
Ser422 |
RERSRTGsESSQTGT |
Homo sapiens |
|
| pmid |
sentence |
| 15071500 |
S6k1/s6k2 specifically phosphorylate ser422 in vitro. Substitution of ser422 with ala results in a loss of activity in an in vivo translation assay, indicating that phosphorylation of this site plays an important role in eif4b function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA1 | up-regulates
phosphorylation
|
EIF4B |
0.519 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123993 |
Ser422 |
RERSRTGsESSQTGT |
Homo sapiens |
|
| pmid |
sentence |
| 15071500 |
S6k1/s6k2 specifically phosphorylate ser422 in vitro. Substitution of ser422 with ala results in a loss of activity in an in vivo translation assay, indicating that phosphorylation of this site plays an important role in eif4b function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinK/CDK13 | up-regulates activity
phosphorylation
|
EIF4B |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273116 |
Ser422 |
RERSRTGsESSQTGT |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 36882522 |
CDK13 directly phosphorylates 4E-BP1 at Thr46 and eIF4B at Ser422; genetically or pharmacologically inhibiting CDK13 disrupts mRNA translation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK13 | up-regulates activity
phosphorylation
|
EIF4B |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273115 |
Ser422 |
RERSRTGsESSQTGT |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 36882522 |
CDK13 directly phosphorylates 4E-BP1 at Thr46 and eIF4B at Ser422; genetically or pharmacologically inhibiting CDK13 disrupts mRNA translation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates
phosphorylation
|
EIF4B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181536 |
Ser422 |
RERSRTGsESSQTGT |
Homo sapiens |
|
| pmid |
sentence |
| 18836482 |
Using an in vitro kinase assay, we found that pkb can directly phosphorylate eif4b on serine 422 (ser422). This was prevented by pretreatment of cells with the phosphatidylinositol 3-kinase (pi3k) inhibitor ly294002 or pharmacological inhibition of pkb. Phosphorylation regultes the activation of eukaryotic translation initiation factor 4b. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF4B | up-regulates activity
binding
|
EIF4A1 |
0.874 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261293 |
|
|
in vitro |
|
| pmid |
sentence |
| 11418588 |
Either eIF4B or eIF4H stimulated the initial rate and amplitude of eIF4A-dependent duplex unwinding, and the magnitude of stimulation is dependent on duplex stability |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
EIF3_complex | up-regulates activity
stabilization
|
EIF4B |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269158 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17581632 |
EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
| + |
EIF4B | form complex 
binding
|
48S_initiation_complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269165 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35489072 |
In eukaryotes, mRNA is recruited to the 43S pre-initiation complex (43S PIC), which consists of the 40S ribosomal subunit, translation initiation factors eIF1, eIF1A, eIF3, eIF5, and a ternary complex (TC) composed of eIF2, GTP and Met-tRNAiMet. 43S PIC binds to the 5′ end of the mRNA and scans along the 5′ untranslated region (5′UTR) in the 3′ direction to find the start codon (AUG) within the context of an optimal Kozak sequence. Start codon recognition stabilizes the 48S initiation complex (48S IC), initiates dissociation of eIF1, eIF1A, eIF2 and eIF5, and promotes recruitment of the 60S ribosomal subunit to form 80S IC ready to enter the elongation cycle of protein synthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
4.0
EIF4B
- 
- 