Summary

Name CCNC
Full Name Cyclin-C
Synonyms SRB11 homolog, hSRB11
Primary ID P24863
Links - -
Type protein
Relations 7
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding CKM complex 0.919
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CyclinC/CDK3 0.682
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CyclinC/CDK19 0.91
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CCNC 0.419
Publications: 1 Organism: Homo Sapiens