Summary

Name HES1
Full Name Transcription factor HES-1
Synonyms Class B basic helix-loop-helix protein 39, bHLHb39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, hHL | BHLHB39, HL, HRY
Primary ID Q14469
Links - -
Type protein
Relations 44
Pathways Acute Myeloid Leukemia, FAP: In vitro induction of adipogenesis, FAP: Glucocorticoids, FAP: Notch, FLT3-ITD in AML, NOTCH Signaling, NOTCH Signaling and Myogenesis, Pericyte: In vitro induction of adipogenesis, Retinoic acid Signaling, Satellite: NOTCH, Tnfa_Notch_crosstalk
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation HES1 0.334
Publications: 2 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNND2 0.358
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FLT3 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NEUROG1 0.357
Publications: 1 Organism: Mus Musculus
Pathways:Retinoic acid Signaling
+ down-regulates activity img/direct_inhibition.png transcriptional regulation MYOD1 0.3
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DTX1 0.321
Publications: 1 Organism: Homo Sapiens
Tissue: Osteosarcoma Cell
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ASCL1 0.457
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:Retinoic acid Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation E2F1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation HES1 0.378
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png binding HES1 0.583
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation NOC3L 0.2
Publications: 1 Organism: Sus Scrofa
+ down-regulates img/indirect_inhibition.png Adipogenesis 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.253
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.374
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RBPJ 0.583
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation RCAN1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png NR3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NEUROG2 0.327
Publications: 1 Organism: Mus Musculus
Pathways:Retinoic acid Signaling
+ up-regulates quantity img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.594
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HES1 0.348
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NR3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.252
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HES1 0.673
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling
+ up-regulates quantity by expression img/indirect-activation.png HES1 0.281
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RBPJ/NOTCH 0.673
Publications: 1 Organism: Mus Musculus
Tissue: Heart
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.252
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ATOH1 0.491
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HES1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation HES1 0.583
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTGDS 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOD1 0.3
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.764
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling