3.0
Summary
| Name |  MSNView Modifications |
| Full Name | Moesin |
| Synonyms | Membrane-organizing extension spike protein |
| Primary ID | P26038 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (PubMed:27405666). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | STK10 | up-regulates activity 
phosphorylation
|
MSN | 0.388 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCQ |
phosphorylation
|
MSN | 0.451 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDC42BPB | up-regulates activity
phosphorylation
|
MSN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LRRK2 | up-regulates activity
phosphorylation
|
MSN | 0.556 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | RHOA | up-regulates activity
phosphorylation
|
MSN | 0.615 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ROCK1 | up-regulates activity
phosphorylation
|
MSN | 0.686 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | MSN | form complex 
binding
|
MSN/PDZD8 | 0.32 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MSN | up-regulates 
|
Platelet_aggregation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |