Summary

Name PLN
Full Name Cardiac phospholamban
Synonyms PLB | PLB
Primary ID P26678
Links - -
Type protein
Relations 5
Function Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PLN 0.462
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation PLN 0.295
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation PLN 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PLN 0.514
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates activity img/direct_inhibition.png binding ATP2A2 0.745
Publications: 1 Organism: Mus Musculus