Summary

Name TEAD1
Full Name Transcriptional enhancer factor TEF-1
Synonyms NTEF-1, Protein GT-IIC, TEA domain family member 1, TEAD-1, Transcription factor 13, TCF-13 | TCF13, TEF1
Primary ID P28347
Links - -
Type protein
Relations 11
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.277
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MSLN 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXM1 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BMP4 0.262
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TEAD1 0.902
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5 0.329
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO3 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TEAD1 0.86
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO 0.313
Publications: 1 Organism: Homo Sapiens