| + |
IL12B | form complex 
binding
|
Interleukin-23 receptor-ligand complex |
0.756 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280726 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression 
transcriptional regulation
|
IL12B |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249500 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12A | up-regulates 
binding
|
IL12B |
0.849 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27619 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7527811 |
However, a proper conformation required for high affinity binding is achieved only when p40 is associated with a p35 subunit or another p40 subunit. When p40 is associated with a p35 subunit, the heterodimer acts as an agonist mediating biologic activity. However, when p40 associates with another p40, the homodimer behaves as an antagonist in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12B | up-regulates
binding
|
IL12RB1 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7527811 |
Characterization of the p40 proteins for binding and bioactivity showed that both the p40 monomer and dimer inhibited 125i-labeled il-12 binding to il-12r, but the 80-kda species, having a 50% inhibitory concentration (ic50) of 20 to 70 ng/ml, was at least 20-fold more effective than the monomer. The results suggest that the il-12 p40 subunit contains the essential epitopes for receptor binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
IL12B
- 
- 