3.0
Summary
| Name |  SHMT2View Modifications |
| Full Name | Serine hydroxymethyltransferase, mitochondrial |
| Synonyms | SHMT, Glycine hydroxymethyltransferase, Serine methylase | |
| Primary ID | P34897 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Pathways | One-carbon Metabolism |
| Function | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:29364879, PubMed:25619277). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SIRT5 | down-regulates activity 
post translational modification
|
SHMT2 | 0.237 |
| Publications: | 1 | |||
| + | SHMT2 | up-regulates quantity 
chemical modification
|
glycine | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | One-carbon Metabolism | |||
| + | SHMT2 | up-regulates quantity
chemical modification
|
(6R)-5,10-methylenetetrahydrofolate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | One-carbon Metabolism | |||
| + | MYC | up-regulates quantity by expression
transcriptional regulation
|
SHMT2 | 0.298 |
| Publications: | 1 | Organism: | Homo Sapiens | |