| + |
RHOA | up-regulates activity 
phosphorylation
|
RDX |
0.49 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268430 |
Thr564 |
AGRDKYKtLRQIRQG |
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 35267019 |
Rev-erbα interacted with OPHN-1, promoted RhoA activity and phosphorylation of ERM. etection of phosphorylated ezrin (Thr567)/radixin (Thr564)/moesin (Thr558)(p-ERM) in Rev-erbαfl/flCre− and Rev-erbαfl/flPF4Cre+ platelets using phospho-specific antibodies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROCK1 | up-regulates activity
phosphorylation
|
RDX |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248994 |
Thr564 |
AGRDKYKtLRQIRQG |
Mus musculus |
Swiss-3T3 Cell |
| pmid |
sentence |
| 9456324 |
A peak of the phosphopeptide, in which only T573 was phosphorylated, was not detected. Quantitative analyses revealed that _100% of T564, but at most _40% of T573, was phosphorylated when C-rad was incubated with Rho-Kc for 1 h. Then we concluded that the major and primary phosphorylation site of radixin by Rho-kinase was T564 and referred to the Rho-Kcphosphorylated C-rad as T564-phosphorylated C-rad. | In this study, we found that the T564 phosphorylation of radixin markedly suppressed its head-to-tail association. This suggests that the T564-phosphorylation of radixin (and probably also the phosphorylation of ezrin T567 and moesin T558) keeps them open and active. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ROCK1 |
phosphorylation
|
RDX |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248995 |
Thr573 |
RQIRQGNtKQRIDEF |
in vitro |
|
| pmid |
sentence |
| 9456324 |
A peak of the phosphopeptide, in which only T573 was phosphorylated, was not detected. Quantitative analyses revealed that _100% of T564, but at most _40% of T573, was phosphorylated when C-rad was incubated with Rho-Kc for 1 h. Then we concluded that the major and primary phosphorylation site of radixin by Rho-kinase was T564 and referred to the Rho-Kcphosphorylated C-rad as T564-phosphorylated C-rad. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
VPS11 | up-regulates activity
binding
|
RDX |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261312 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21148287 |
Vps11 was found to interact with radixin. ERM proteins and the HOPS complex are required for the transition from early to late endosomes. We report that an interaction between subunits of the HOPS complex and the ERM (ezrin, radixin, moesin) proteins is required for the delivery of EGF receptor (EGFR) to lysosomes. Inhibiting either ERM proteins or the HOPS complex leads to the accumulation of the EGFR into early endosomes, delaying its degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RDX | up-regulates 
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268433 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 35267019 |
Rev-erbα interacted with OPHN-1, promoted RhoA activity and phosphorylation of ERM. etection of phosphorylated ezrin (Thr567)/radixin (Thr564)/moesin (Thr558)(p-ERM) in Rev-erbαfl/flCre− and Rev-erbαfl/flPF4Cre+ platelets using phospho-specific antibodies. Taken together, these results suggest that Rev-erbα potentiates platelet activation via an OPHN-1-mediated RhoA/ERM signalling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB5 | down-regulates quantity by repression 
transcriptional regulation
|
RDX |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253809 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21132541 |
Our result verified CREB5 biological regulation module in the upstream of frontal cortex of HIVE-control patients (MAPKAPK3 activation; DGKG, LY96, TNFRSF11B inhibition) and downstream (ATP6V0E1, CFB, DGKG, MX1, TGFBR3 activation; LGALS3BP, RASGRP3, RDX, STAT1 inhibition), |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Bladder Transitional Cell Carcinoma Cell |
3.0
RDX
- 
- 