| + |
NEK6 | down-regulates activity 
phosphorylation
|
BSG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273882 |
Ser368 |
GSAPLKSsGQHQNDK |
Homo sapiens |
|
| pmid |
sentence |
| 31016558 |
These results indicate that NEK6 directly interacts with CD147 and phosphorylates the protein at serine-252 in Huh-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FYN | up-regulates activity 
phosphorylation
|
BSG (isoform 2) |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273999 |
Tyr140 |
PVTDWAWyKITDSED |
Homo sapiens |
Melanoma Cell Line |
| pmid |
sentence |
| 32291412 |
Our findings demonstrated that Fyn directly phosphorylates CD147 at Y140 and Y183. Moreover, the CD147-FF (Y140F/Y183F) mutation impaired the interaction between CD147 and GnT-V, leading to decreased CD147 glycosylation and membrane recruitment. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274000 |
Tyr183 |
MEADPGQyRCNGTSS |
Homo sapiens |
Melanoma Cell Line |
| pmid |
sentence |
| 32291412 |
Our findings demonstrated that Fyn directly phosphorylates CD147 at Y140 and Y183. Moreover, the CD147-FF (Y140F/Y183F) mutation impaired the interaction between CD147 and GnT-V, leading to decreased CD147 glycosylation and membrane recruitment. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FBXO22 | down-regulates quantity by destabilization
binding, ubiquitination
|
BSG |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272787 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28117675 |
FBXO22 mediates poly-ubiquitination and degradation of CD147. Classically, F-box protein together with Skp1 and Cullin 1 constitute Skp-Cullin-F box ubiquitin E3 ligase (SCFs) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273452 |
|
|
Homo sapiens |
HEK-293 Cell, SMMC-7721 Cell, A549-CR Cell |
| pmid |
sentence |
| 28117675 |
F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination, ubiquitination
|
BSG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272789 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28117675 |
FBXO22 mediates poly-ubiquitination and degradation of CD147. Classically, F-box protein together with Skp1 and Cullin 1 constitute Skp-Cullin-F box ubiquitin E3 ligase (SCFs) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273453 |
|
|
Homo sapiens |
HEK-293 Cell, SMMC-7721 Cell, A549-CR Cell |
| pmid |
sentence |
| 28117675 |
F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
BSG
- 
- 