Summary

Name NEK6
Full Name Serine/threonine-protein kinase Nek6
Synonyms Never in mitosis A-related kinase 6, NimA-related protein kinase 6, Protein kinase SID6-1512
Primary ID Q9HC98
Links - -
Type protein
Relations 17
Function Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation KIF11 0.464
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EML4 0.255
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ACD 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NEK6 0.67
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KIF20A 0.358
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PSMD2 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BSG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SGK1 0.344
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.375
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation NUP98 0.324
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.343
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HSPA1A 0.439
Publications: 1 Organism: In Vitro