| + |
SP3 | up-regulates quantity by expression 
transcriptional regulation
|
SCNN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251951 |
|
|
Homo sapiens |
Lung Epithelial Cell |
| pmid |
sentence |
| 12684058 |
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | down-regulates quantity by repression 
transcriptional regulation
|
SCNN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251947 |
|
|
Homo sapiens |
Alveolar Epithelial Cell |
| pmid |
sentence |
| 15755725 |
Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCNN1A | up-regulates activity 
binding
|
CACNA1H |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269272 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30736831 |
This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β- and γ-ENaC subunits could be co-immunoprecipitated with Cav3.2 calcium channels from brain lysates, dorsal horn and lumbar dorsal root ganglia. Αβγ-ENaC channels enhanced Cav3.2 calcium channel trafficking to the plasma membrane in tsA-201 cells. This effect was reciprocal such that Cav3.2 channel expression also enhanced β-ENaC trafficking to the cell surface. these findings reveal ENaC as an interactor and potential regulator of Cav3.2 calcium channels expressed in neuronal tissues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MLLT3 | down-regulates quantity by repression
transcriptional regulation
|
SCNN1A |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251944 |
|
|
Homo sapiens |
Renal Epithelial Cell |
| pmid |
sentence |
| 20159978 |
AF9/MLLT3 contributes to the regulation of the gene encoding the epithelial sodium channel alpha, ENaCalpha, in renal tubular cells. Specifically, increases in AF9 protein lead to a reduction in ENaCalpha expression and changes in AF9 activity appear to be an important component of aldosterone signaling in the kidney. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
dexamethasone | up-regulates
|
SCNN1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251945 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 10722699 |
Dexamethasone induces α-ENaCmRNA expression in lung epithelial A549 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNF | down-regulates quantity by repression
transcriptional regulation
|
SCNN1A |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251954 |
|
|
Homo sapiens |
Alveolar Epithelial Cell |
| pmid |
sentence |
| 16877633 |
TNF, a proinflammatory cytokine present in several lung pathologies, decreases the expression and activity of the epithelial Na(+) channel (ENaC) by approximately 70% in alveolar epithelial cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEDD4L | down-regulates quantity by destabilization 
ubiquitination
|
SCNN1A |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251948 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15586017 |
The serum and glucocorticoid inducible kinase 1 (SGK1) is induced in the aldosterone sensitive distal nephron (ASDN) where it may stimulate Na reabsorption, partly by inhibiting ubiquitin ligase Nedd4-2-mediated retrieval of epithelial Na+ channel ENaC from the luminal membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCNN1A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269275 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26772908 |
The epithelial sodium channel (ENaC) is composed of three homologous subunits and allows the flow of Na(+) ions across high resistance epithelia, maintaining body salt and water homeostasis. ENaC dependent reabsorption of Na(+) in the kidney tubules regulates extracellular fluid (ECF) volume and blood pressure by modulating osmolarity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGA2 | down-regulates quantity by repression
transcriptional regulation
|
SCNN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251946 |
|
|
Rattus norvegicus |
Parotid Acinar Cell |
| pmid |
sentence |
| 11390395 |
Expression of endogenous alpha-ENaC gene in salivary Pa-4 cells is suppressed by an ectopic HMGI-C overexpression. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SCNN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251950 |
|
|
Homo sapiens |
Lung Epithelial Cell |
| pmid |
sentence |
| 12684058 |
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SCNN1A
- 
- 