| + |
MAPK1 | up-regulates quantity by stabilization 
phosphorylation
|
TAGLN2 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265221 |
Ser145 |
ARDDGLFsGDPNWFP |
Homo sapiens |
SW-1990 Cell |
| pmid |
sentence |
| 30041673 |
ERK2 interacted with 29-31 amino acids of transgelin-2 and subsequently phosphorylated the S145 residue of transgelin-2. S145 phosphorylation of transgelin-2 played important roles in cell proliferation and tumorigenesis of PDAC.| We found that the protein stability of transgelin-2 was regulated by KRAS. ERK-mediated phosphorylation resulted in accumulation of transgelin-2 protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK14 | down-regulates activity 
phosphorylation
|
TAGLN2 |
0.324 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265105 |
Ser163 |
KENPRNFsDNQLQEG |
|
|
| pmid |
sentence |
| 21577206 |
This newly identified oncogene–tumor suppressor cascade, where oncogenic PFTK1 inactivates a tumor suppressor gene TAGLN2 via phosphorylation|. Our data therefore underline much importance for S83 and S163 residues on TAGLN2 in its actin-binding capacity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265103 |
Ser83 |
PVKKIQAsTMAFKQM |
|
|
| pmid |
sentence |
| 21577206 |
This newly identified oncogene–tumor suppressor cascade, where oncogenic PFTK1 inactivates a tumor suppressor gene TAGLN2 via phosphorylation|. Our data therefore underline much importance for S83 and S163 residues on TAGLN2 in its actin-binding capacity. |
|
| Publications: |
2 |
| + |
TAGLN2 | down-regulates activity
binding
|
ACTB |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265104 |
|
|
|
|
| pmid |
sentence |
| 21577206 |
Taken together, our data propose a novel, oncogene-tumor suppressor interplay, where oncogenic PFTK1 confers HCC cell motility through inactivating the actin-binding motile suppressing function of TAGLN2 via phosphorylation. |
|
| Publications: |
1 |
3.0
TAGLN2
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