Summary

Name MAPK1
Full Name Mitogen-activated protein kinase 1
Synonyms MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2 | ERK2, PRKM1, PRKM2
Primary ID P28482
Links - -
Type protein
Relations 453
Pathways Glucocorticoid Receptor
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.10
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUND 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.12
Publications: 6 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LIFR 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POU5F1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization PPARG
Publications: 7 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ESPL1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SOS1
Publications: 6 Organism: Chlorocebus Aethiops, Homo Sapiens
Tissue: Lung, Breast
+ up-regulates img/direct-activation.png phosphorylation SREBF1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.06
Publications: 3 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.07
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR4A2
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1A 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAFA
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIC
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation THRB 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation THRB 0.04
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TFEB 0.05
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PPP1R9B 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.05
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RGS19 0.05
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TOB1 0.05
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation DUSP6 0.26
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ERF 0.07
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POLR2A 0.14
Publications: 23 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTTG1 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RCAN1 0.02
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation APBB1
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MITF 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ABI1 0.11
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD1
Publications: 11 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NR5A1 0.03
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation SMAD3 0.12
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3
Publications: 9 Organism: Homo Sapiens
Tissue: Lung, Breast
+ down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TPR 0.12
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NUP50 0.11
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.27
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NUP50 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPHK1 0.10
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NR3C1 0.11
Publications: 1 Organism: In Vitro
Pathways:Glucocorticoid Receptor
+ up-regulates img/direct-activation.png phosphorylation EP300 0.15
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ZFP36 0.06
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NDE1 0.04
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.16
Publications: 4 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates img/direct-activation.png phosphorylation RUNX1 0.07
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EXOC7 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.09
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.16
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TNFRSF1A 0.07
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RUNX1 0.07
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.02
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.05
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.02
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.63
Publications: 6 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation H3F3A 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TFCP2 0.04
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AMPH 0.01
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation PGR 0.04
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.08
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DUSP1 0.36
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.18
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PCYT1A
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates activity img/direct-activation.png phosphorylation ELK1
Publications: 4 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation BCL6 0.05
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP2R5C 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DUSP1 0.36
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.11
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.18
Publications: 5 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation CSNK2A1 0.13
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PARP1 0.25
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.38
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.18
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.12
Publications: 6 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation SPHK2 0.05
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.13
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARRB1 0.10
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB10 0.05
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation LCK 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png phosphorylation CEP55 0.11
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SREBF2 0.08
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KRT8 0.12
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.22
Publications: 10 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation DUSP16 0.05
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation MKL1 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KLC1 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAPN2 0.09
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PLA2G4A
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AR
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NEFH 0.04
Publications: 3 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT 0.11
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation JAK2 0.15
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation NUP153
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SORBS3
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MYB 0.06
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.16
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation NOX5 0.04
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.04
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation STIM1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDE4D
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KHDRBS1 0.12
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SP1 0.16
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LCK 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.18
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation MYC
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation TH 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB2 0.09
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDE4C 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.19
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.19
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GTF2I 0.12
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NFATC4 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.09
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPTOR 0.11
Publications: 3 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.22
Publications: 5 Organism: Homo Sapiens, Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation PDE4D 0.06
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SP3 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DAPK1 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BMF 0.03
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.09
Publications: 2 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation SLC9A1 0.09
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5A
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation IL16 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN7 0.07
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLCB1 0.07
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MED1 0.12
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation UBTF 0.11
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PITPNM1 0.02
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.18
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NR4A1 0.07
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.16
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRDX6 0.12
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates img/direct-activation.png phosphorylation IER3 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK5 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RORA
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation MAPK1
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.13
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.13
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK1
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK1
Publications: 2
Pathways:Glucocorticoid Receptor
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK1 0.47
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.10
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PAK1 0.15
Publications: 1 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation GORASP2 0.10
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MBP 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MBP 0.15
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD4
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP2K1
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ELK1
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.06
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPRR 0.06
Publications: 1
+ img/unknown.png phosphorylation RPS3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EIF4EBP1 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF2AK2 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAD 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ERF 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYC
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1B 0.03
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1G 0.03
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.11
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.20
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.43
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF
Publications: 1 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation EWSR1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LIPE 0.05
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation MAPK1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.03
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation MAPK1
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding, dephosphorylation MAPK1 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown MAPK1
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.06
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.04
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png binding MAPK1 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.16
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ down-regulates img/indirect_inhibition.png unknown MAPK14
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates img/indirect-activation.png unknown MAP3K5 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png unknown MAPK1 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK1 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown MAPK1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSK3B 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown SLC2A4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.58
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.36