Summary

Name HSPA9
Full Name Stress-70 protein, mitochondrial
Synonyms 75 kDa glucose-regulated protein, GRP-75, Heat shock 70 kDa protein 9, Mortalin, MOT, Peptide-binding protein 74, PBP74 | GRP75, HSPA9B, mt-HSP70
Primary ID P38646
Links - -
Type protein
Relations 5
Function Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation HSPA9 0.2
Publications: 2 Organism: Homo Sapiens
+ form complex img/form-complex.png binding TIM23 complex 0.679
Publications: 1
+ up-regulates activity img/direct-activation.png relocalization iron-sulfur cluster 0.8
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding MVD 0.348
Publications: 1 Organism: Chlorocebus Aethiops