| + |
AKT1 | up-regulates activity 
phosphorylation
|
MVD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265891 |
Ser96 |
LARKRRNsRDGDPLP |
Mus musculus |
|
| pmid |
sentence |
| 25378391 |
Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser96. These data suggest that Akt regulates Rac1 activity by directly phosphorylating MDD at Ser96, which augments Rac1 geranylgeranylation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MVD | up-regulates quantity by stabilization 
|
HRAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265888 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12646231 |
An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2. These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras. Ras and its oncogenic forms act as key players in controlling proliferation of normal and cancerous cells. Assigning mot-2 upstream of p21Ras offers an important mechanism for influence over cell proliferation. Therefore, we ra tionaled to investigate if overexpression of MPD could affect the steady state levels of Ras by affecting its prenylationTransient transfections of MPD-myc in COS 7 cells resulted in higher stable levels of Ras as compared to the untransfected cells (Fig. 3A, compare lanes 4 and 8 and Fig. 3B) |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MVD | up-regulates quantity by stabilization
|
KRAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265887 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12646231 |
An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2. These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras. Ras and its oncogenic forms act as key players in controlling proliferation of normal and cancerous cells. Assigning mot-2 upstream of p21Ras offers an important mechanism for influence over cell proliferation. Therefore, we ra tionaled to investigate if overexpression of MPD could affect the steady state levels of Ras by affecting its prenylationTransient transfections of MPD-myc in COS 7 cells resulted in higher stable levels of Ras as compared to the untransfected cells (Fig. 3A, compare lanes 4 and 8 and Fig. 3B) |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MVD | up-regulates activity
lipidation
|
RAC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265892 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25378391 |
Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser96. These data suggest that Akt regulates Rac1 activity by directly phosphorylating MDD at Ser96, which augments Rac1 geranylgeranylation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MVD | up-regulates quantity by stabilization
|
NRAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265889 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12646231 |
An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2. These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras. Ras and its oncogenic forms act as key players in controlling proliferation of normal and cancerous cells. Assigning mot-2 upstream of p21Ras offers an important mechanism for influence over cell proliferation. Therefore, we ra tionaled to investigate if overexpression of MPD could affect the steady state levels of Ras by affecting its prenylationTransient transfections of MPD-myc in COS 7 cells resulted in higher stable levels of Ras as compared to the untransfected cells (Fig. 3A, compare lanes 4 and 8 and Fig. 3B) |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
HSPA9 | down-regulates activity 
binding
|
MVD |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265890 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12646231 |
Mortalin binds to mevalonate pyrophosphate decarboxyl ase in mammalian cell. Mot-2 inactivates MPD resulting in decreased amounts of the steady state Ras protein. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
MVD
- 
- 