Relation Results

Summary

Name MVD
Full Name Diphosphomevalonate decarboxylase
Synonyms Mevalonate (diphospho)decarboxylase, MDDase, Mevalonate pyrophosphate decarboxylase | MPD
Primary ID P53602
Links - -
Type protein
Relations 6
Function Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) path ...
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Type: Score: Layout: SPV 
0.20.20.20.20.20.343AKT1MVDHRASKRASRAC1NRASHSPA9

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKT1up-regulates activity img/direct-activation.png phosphorylation MVD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265891 Ser96 LARKRRNsRDGDPLP Mus musculus
pmid sentence
Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser96. These data suggest that Akt regulates Rac1 activity by directly phosphorylating MDD at Ser96, which augments Rac1 geranylgeranylation.
Publications: 1 Organism: Mus Musculus
+ MVDup-regulates quantity by stabilization img/indirect-activation.png HRAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265888 Chlorocebus aethiops
pmid sentence
An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2. These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras. Ras and its oncogenic forms act as key players in controlling proliferation of normal and cancerous cells. Assigning mot-2 upstream of p21Ras offers an important mechanism for influence over cell proliferation. Therefore, we ra tionaled to investigate if overexpression of MPD could affect the steady state levels of Ras by affecting its prenylationTransient transfections of MPD-myc in COS 7 cells resulted in higher stable levels of Ras as compared to the untransfected cells (Fig. 3A, compare lanes 4 and 8 and Fig. 3B)
Publications: 1 Organism: Chlorocebus Aethiops
+ MVDup-regulates quantity by stabilization img/indirect-activation.png KRAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265887 Chlorocebus aethiops
pmid sentence
An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2. These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras. Ras and its oncogenic forms act as key players in controlling proliferation of normal and cancerous cells. Assigning mot-2 upstream of p21Ras offers an important mechanism for influence over cell proliferation. Therefore, we ra tionaled to investigate if overexpression of MPD could affect the steady state levels of Ras by affecting its prenylationTransient transfections of MPD-myc in COS 7 cells resulted in higher stable levels of Ras as compared to the untransfected cells (Fig. 3A, compare lanes 4 and 8 and Fig. 3B)
Publications: 1 Organism: Chlorocebus Aethiops
+ MVDup-regulates activity img/direct-activation.png lipidation RAC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265892 Mus musculus
pmid sentence
Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser96. These data suggest that Akt regulates Rac1 activity by directly phosphorylating MDD at Ser96, which augments Rac1 geranylgeranylation.
Publications: 1 Organism: Mus Musculus
+ MVDup-regulates quantity by stabilization img/indirect-activation.png NRAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265889 Chlorocebus aethiops
pmid sentence
An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2. These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras. Ras and its oncogenic forms act as key players in controlling proliferation of normal and cancerous cells. Assigning mot-2 upstream of p21Ras offers an important mechanism for influence over cell proliferation. Therefore, we ra tionaled to investigate if overexpression of MPD could affect the steady state levels of Ras by affecting its prenylationTransient transfections of MPD-myc in COS 7 cells resulted in higher stable levels of Ras as compared to the untransfected cells (Fig. 3A, compare lanes 4 and 8 and Fig. 3B)
Publications: 1 Organism: Chlorocebus Aethiops
+ HSPA9down-regulates activity img/direct_inhibition.png binding MVD 0.343
Identifier Residue Sequence Organism Cell Line
SIGNOR-265890 Chlorocebus aethiops
pmid sentence
Mortalin binds to mevalonate pyrophosphate decarboxyl ase in mammalian cell. Mot-2 inactivates MPD resulting in decreased amounts of the steady state Ras protein.
Publications: 1 Organism: Chlorocebus Aethiops
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