3.0
Summary
| Name |  CSKView Modifications |
| Full Name | Tyrosine-protein kinase CSK |
| Synonyms | C-Src kinase, Protein-tyrosine kinase CYL |
| Primary ID | P41240 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Pathways | EBV infection, Mitochondrial dynamics in T cell exhaustion, T cell activation |
| Inhibitors | lapatinib |
| Function | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates activity 
phosphorylation
|
CSK | 0.343 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSK | up-regulates
phosphorylation
|
PTPRC | 0.482 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | T cell activation | |||
| + | CSK | up-regulates activity
phosphorylation
|
CSK | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | EBV infection, T cell activation | |||
| + | CSK | down-regulates 
phosphorylation
|
LCK | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | T cell activation | |||
| + | CSK | down-regulates
phosphorylation
|
LYN | 0.517 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | EBV infection | |||
| + | CSK | down-regulates activity
phosphorylation
|
FGR | 0.516 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CSK | down-regulates
phosphorylation
|
SRC | 0.55 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSK | up-regulates activity
phosphorylation
|
PECAM1 | 0.531 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | CSK | up-regulates
binding
|
NOTCH1 | 0.285 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IGF1R | up-regulates 
|
CSK | 0.353 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | EBV infection | |||
| + | CSK | down-regulates activity
phosphorylation
|
ITCH | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CREBBP | up-regulates
binding
|
CSK | 0.514 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | lapatinib | down-regulates activity
chemical inhibition
|
CSK | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |