3.0
Summary
| Name |  MAGEA6
|
| Full Name | Melanoma-associated antigen 6 |
| Synonyms | Cancer/testis antigen 1.6, CT1.6, MAGE-6 antigen, MAGE3B antigen | MAGE6 |
| Primary ID | P43360 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:31267705, PubMed:17942928, PubMed:20864041). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:31267705}. |
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