Summary

Name IER3
Full Name Radiation-inducible immediate-early gene IEX-1
Synonyms Differentiation-dependent gene 2 protein, Protein DIF-2, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, Protein PRG1 | DIF2, IEX1, PRG1
Primary ID P46695
Links - -
Type protein
Relations 3
Function May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation IER3 0.527
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png post transcriptional regulation IER3 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png binding PPP2R5C 0.517
Publications: 1 Organism: Homo Sapiens