| + |
SPP1 | up-regulates quantity by expression 
transcriptional regulation
|
ALDH1A3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282548 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
The OPN/SPP1 KD CAF-CM treated cells significantly reduced the OPN/SPP1, ALDH1A1, ALDH1A3, CD44, KLF4, SOX2, OCT3/4, SOX9, BMI1, and NANOG |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD44 | up-regulates quantity by expression
transcriptional regulation
|
ALDH1A3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282557 |
|
|
Homo sapiens |
Fibroblast, Pancreatic Ductal Carcinoma Cell |
| pmid |
sentence |
| 34418441 |
QRT-PCR data revealed that the CD44 KD in CAF-CM treated PC cells significantly decreased mRNA expression levels of CD44, OPN/SPP1, ALDH1A1, ALDH1A3, KLF4, BMI1, and SOX2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALDH1A3 | up-regulates quantity 
chemical modification
|
all-trans-retinoic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21621639 |
All-trans-retinoic acid (atRA) provides essential support to diverse biological systems and physiological processes.| An accrual of biochemical, physiological and genetic data have identified specific functional outcomes for the retinol dehydrogenases, RDH1, RDH10, and DHRS9, as physiological catalysts of the first step in atRA biosynthesis, and for the retinal dehydrogenases RALDH1, RALDH2, and RALDH3, as catalysts of the second and irreversible step. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic Acid Metabolism |
| + |
ALDH1A3 | down-regulates quantity 
chemical modification
|
retinal |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21621639 |
All-trans-retinoic acid (atRA) provides essential support to diverse biological systems and physiological processes.| An accrual of biochemical, physiological and genetic data have identified specific functional outcomes for the retinol dehydrogenases, RDH1, RDH10, and DHRS9, as physiological catalysts of the first step in atRA biosynthesis, and for the retinal dehydrogenases RALDH1, RALDH2, and RALDH3, as catalysts of the second and irreversible step. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic Acid Metabolism |
4.0
ALDH1A3
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